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| 13.02.2022 | 14:30 | ASD Pineto Calcio | - | Aurora Alto Casertano | 1:0 | |
| 14:30 | Chieti Calcio | - | Porto D'Ascoli | 2:1 | ||
| 14:30 | GSD Castelfidardo | - | Alma Juventus Fano | 0:1 | ||
| 14:30 | Matese | - | Vastogirardi | 3:1 | ||
| 14:30 | Montegiorgio Calcio | - | US Recanatese | 1:1 | ||
| 14:30 | SN Notaresco | - | Nereto | 0:0 | ||
| 14:30 | Tolentino | - | ASD Trastevere | 1:0 | ||
| 14:30 | Vastese Calcio | - | Castelnuovo Vomano | 2:0 | ||
| 14:30 | Sambenedettese | - | Atletico Terme Fiuggi | 3:0 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
US Recanatese | 20 | 12 | 5 | 3 | 38:13 | 25 | 41 |
| 2 |
|
ASD Trastevere | 20 | 12 | 3 | 5 | 35:18 | 17 | 39 |
| 3 |
|
Atletico Terme Fiuggi | 20 | 11 | 2 | 7 | 28:24 | 4 | 35 |
| 4 |
|
Porto D'Ascoli | 20 | 9 | 6 | 5 | 23:18 | 5 | 33 |
| 5 |
|
ASD Pineto Calcio | 20 | 8 | 8 | 4 | 27:14 | 13 | 32 |
| 6 |
|
Vastese Calcio | 20 | 8 | 8 | 4 | 30:20 | 10 | 32 |
| 7 |
|
SN Notaresco | 20 | 9 | 5 | 6 | 27:25 | 2 | 32 |
| 8 |
|
Tolentino | 20 | 9 | 4 | 7 | 21:15 | 6 | 31 |
| 9 |
|
Chieti Calcio | 20 | 8 | 6 | 6 | 22:21 | 1 | 30 |
| 10 |
|
Vastogirardi | 20 | 8 | 5 | 7 | 30:33 | -3 | 29 |
| 11 |
|
Alma Juventus Fano | 20 | 7 | 5 | 8 | 24:23 | 1 | 26 |
| 12 |
|
Sambenedettese | 20 | 7 | 5 | 8 | 20:24 | -4 | 26 |
| 13 |
|
Matese | 20 | 6 | 8 | 6 | 23:22 | 1 | 26 |
| 14 |
|
Montegiorgio Calcio | 20 | 7 | 4 | 9 | 22:24 | -2 | 25 |
| 15 |
|
GSD Castelfidardo | 20 | 6 | 5 | 9 | 16:20 | -4 | 23 |
| 16 |
|
Castelnuovo Vomano | 20 | 5 | 5 | 10 | 28:36 | -8 | 20 |
| 17 |
|
Nereto | 20 | 2 | 5 | 13 | 17:44 | -27 | 11 |
| 18 |
|
Aurora Alto Casertano | 20 | 0 | 3 | 17 | 5:42 | -37 | 3 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
