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| 13.06.2021 | 16:00 | Olympia Agnonese | - | FC Aprilia | 2:4 | |
| 16:00 | ASD Pineto Calcio | - | GSD Castelfidardo | 1:2 | ||
| 16:00 | CynthiAlbalonga | - | Vastogirardi | 3:0 | ||
| 16:00 | Atletico Terme Fiuggi | - | Montegiorgio Calcio | 2:1 | ||
| 16:00 | Real Giulianova | - | Matese | 3:3 | ||
| 16:00 | Porto Sant'Elpidio | - | Castelnuovo Vomano | 3:2 | ||
| 16:00 | US Recanatese | - | SN Notaresco | 4:4 | ||
| 16:00 | FC Rieti | - | Campobasso | 1:2 | ||
| 16:00 | Tolentino | - | Vastese Calcio | 0:2 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Campobasso | 32 | 21 | 8 | 3 | 60:25 | 35 | 71 |
| 2 |
|
SN Notaresco | 32 | 18 | 9 | 5 | 57:30 | 27 | 63 |
| 3 |
|
CynthiAlbalonga | 32 | 13 | 13 | 6 | 47:33 | 14 | 52 |
| 4 |
|
ASD Pineto Calcio | 32 | 14 | 10 | 8 | 41:30 | 11 | 52 |
| 5 |
|
Matese | 32 | 14 | 10 | 8 | 44:37 | 7 | 52 |
| 6 |
|
GSD Castelfidardo | 32 | 12 | 13 | 7 | 38:33 | 5 | 49 |
| 7 |
|
US Recanatese | 32 | 12 | 10 | 10 | 59:43 | 16 | 46 |
| 8 |
|
Castelnuovo Vomano | 32 | 13 | 7 | 12 | 51:52 | -1 | 46 |
| 9 |
|
Vastese Calcio | 32 | 11 | 13 | 8 | 44:36 | 8 | 45 |
| 10 |
|
Montegiorgio Calcio | 32 | 13 | 6 | 13 | 40:39 | 1 | 45 |
| 11 |
|
FC Rieti | 32 | 12 | 7 | 13 | 37:40 | -3 | 43 |
| 12 |
|
FC Aprilia | 32 | 10 | 11 | 11 | 41:46 | -5 | 41 |
| 13 |
|
Atletico Terme Fiuggi | 32 | 8 | 15 | 9 | 39:37 | 2 | 39 |
| 14 |
|
Vastogirardi | 32 | 10 | 9 | 13 | 42:46 | -4 | 39 |
| 15 |
|
Tolentino | 32 | 8 | 12 | 12 | 48:50 | -2 | 36 |
| 16 |
|
Real Giulianova | 32 | 7 | 9 | 16 | 31:47 | -16 | 30 |
| 17 |
|
Porto Sant'Elpidio | 32 | 3 | 5 | 24 | 20:62 | -42 | 14 |
| 18 |
|
Olympia Agnonese | 32 | 3 | 5 | 24 | 23:76 | -53 | 14 |
| Promotion | |
| Play-off | |
| Relégation |
