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| H (Match allé) | Benevento Calcio | - | Pisa SC | 1:0 (0:0) | ||
| R (match retour) | Pisa SC | - | Benevento Calcio | 1:0 (1:0) | ||
| H (Match allé): 17.05.2022 20:30 | R (match retour): 21.05.2022 18:00 | |||||
| H (Match allé) | Brescia Calcio | - | AC Monza | 1:2 (1:1) | ||
| R (match retour) | AC Monza | - | Brescia Calcio | 2:1 (0:1) | ||
| H (Match allé): 18.05.2022 20:00 | R (match retour): 22.05.2022 21:00 | vainqueur: AC Monza | ||||
