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| 05.01.2022 | 14:30 | Virtus CiseranoBergamo | - | Caldiero Terme | 3:0 (1:1, 2:2) tab | |
| 16.01.2022 | 14:30 | AC Prato | - | Follonica Gavorrano | 1:2 | |
| 09.02.2022 | 14:30 | US Recanatese | - | Scandicci Calcio | 5:6 (1:2, 2:2, 2:2) tab | |
| 09.03.2022 | 14:30 | Derthona FBC | - | SC Caronnese | 1:2 | |
| 14:30 | AC Carpi | - | Ponte San Pietro | 2:1 | ||
| 14:30 | Audace Cerignola | - | Gladiator | 4:2 | ||
| 14:30 | Cittanova Interpiana | - | Trapani Calcio | 1:0 | ||
| 20.03.2022 | 14:30 | Castelnuovo Vomano | - | SEF Torres 1903 | 0:3 |
