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| 24.11.2021 | 14:30 | Caldiero Terme | - | US Levico Terme | 3:2 (0:0, 0:0) tab | |
| 14:30 | Delta Rovigo | - | Virtus CiseranoBergamo | 0:2 (0:0) | ||
| 14:30 | Derthona FBC | - | PDHAE | 5:2 (4:0) | ||
| 14:30 | US Breno | - | SC Caronnese | 2:3 (2:2) | ||
| 14:30 | Ponte San Pietro | - | AC Fanfulla 1874 | 5:4 (1:1, 1:1) tab | ||
| 14:30 | Correggese | - | AC Carpi | 0:1 (0:0) | ||
| 14:30 | Sanremese | - | AC Prato | 3:4 (0:1, 2:2) tab | ||
| 14:30 | Follonica Gavorrano | - | Seravezza | 3:1 (1:0) | ||
| 14:30 | Foligno Calcio | - | Scandicci Calcio | 0:2 (0:1) | ||
| 14:30 | ASD Vis Artena | - | SEF Torres 1903 | 2:3 (1:1) | ||
| 14:30 | Gladiator | - | US Bitonto | 1:0 (0:0) | ||
| 14:30 | Santa Maria Cilento | - | Cittanova Interpiana | 3:4 (1:2) | ||
| 14:30 | Trapani Calcio | - | FC Messina | 2:0 (2:0) | ||
| 15:00 | Audace Cerignola | - | Team Altamura | 2:0 (1:0) | ||
| 15.12.2021 | 14:30 | Sambenedettese | - | US Recanatese | 1:2 | |
| 09.03.2022 | 14:30 | CynthiAlbalonga | - | Castelnuovo Vomano | 2:4 tab |
