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| 11.01.2022 | 18:00 | Maccabi Ahi Nazareth | - | Maccabi Petach-Tikva | 2:3 (1:2, 2:2) ap | |
| 18:05 | Agudat Sport Ashdod | - | Maccabi Kabilio Jaffa | 2:4 (1:1, 1:1, 1:1) tab | ||
| 18:10 | Bnei Yehuda Tel Aviv | - | Maccabi Sha'arayim | 2:0 (0:0) | ||
| 18:40 | Hapoel Umm al-Fahm | - | Hapoel Haifa | 4:5 (0:0, 0:0, 0:0) tab | ||
| 19:00 | Ironi Kiryat Shmona | - | Maccabi Tel Aviv | 3:5 (1:1, 2:2, 2:2) tab | ||
| 12.01.2022 | 18:30 | Maccabi Netanya | - | Hapoel Be'er Sheva | 1:2 ap | |
| 19:00 | Maccabi Haifa | - | Beitar Jerusalem | 4:0 | ||
| 13.01.2022 | 19:00 | Hapoel Hadera | - | Bnei Sachnin FC | 3:0 |
