 |
 |
|
|
| 26.03.2022 | 13:45 | AO Trikala | - | Xanthi FC | 1:1 (1:0) | |
| 13:45 | Niki Volou FC | - | Almopos Arideas | 1:0 (1:0) | ||
| 16:00 | Panserraikos | - | Veria FC | 0:1 (0:0) | ||
| 27.03.2022 | 13:45 | Apollon Lárissa | - | Anagennisi Karditsa | 2:1 (1:0) | |
| 13:45 | AE Lárissa | - | Pierikos Katerini | 1:0 (0:0) | ||
| 13:45 | PAOK Saloniki II | - | Thesprotos | 0:0 (0:0) | ||
| 13:45 | Olympiakos Volou | - | AO Kavala | 0:2 (0:0) | ||
| 20.04.2022 | 16:00 | Olympiakos Piraeus II | - | Apollon Pontou | 2:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 25 | 19 | 4 | 2 | 50:18 | 32 | 61 |
| 2 |
|
AE Lárissa | 24 | 15 | 8 | 1 | 34:9 | 25 | 53 |
| 3 |
|
Anagennisi Karditsa | 25 | 13 | 5 | 7 | 38:23 | 15 | 44 |
| 4 |
|
Niki Volou FC | 25 | 11 | 8 | 6 | 30:15 | 15 | 41 |
| 5 |
|
Xanthi FC | 24 | 10 | 10 | 4 | 34:16 | 18 | 40 |
| 6 |
|
AEP Iraklis FC | 24 | 7 | 13 | 4 | 27:17 | 10 | 34 |
| 7 |
|
PAOK Saloniki II | 25 | 8 | 10 | 7 | 28:25 | 3 | 34 |
| 8 |
|
Olympiakos Piraeus II | 24 | 8 | 8 | 8 | 25:26 | -1 | 32 |
| 9 |
|
Almopos Arideas | 24 | 8 | 7 | 9 | 32:26 | 6 | 31 |
| 10 |
|
Thesprotos | 24 | 6 | 8 | 10 | 27:28 | -1 | 26 |
| 11 |
|
Apollon Pontou | 25 | 6 | 8 | 11 | 27:34 | -7 | 26 |
| 12 |
|
Apollon Lárissa | 24 | 6 | 8 | 10 | 18:32 | -14 | 26 |
| 13 |
|
Pierikos Katerini | 25 | 5 | 9 | 11 | 26:35 | -9 | 24 |
| 14 |
|
AO Kavala | 24 | 5 | 7 | 12 | 19:64 | -45 | 22 |
| 15 |
|
Panserraikos | 24 | 4 | 9 | 11 | 25:33 | -8 | 21 |
| 16 |
|
Olympiakos Volou | 25 | 5 | 6 | 14 | 26:41 | -15 | 21 |
| 17 |
|
AO Trikala | 25 | 5 | 6 | 14 | 17:41 | -24 | 21 |
| Play-off | |
| Relégation |
