 |
 |
|
|
| 26.02.2022 | 13:45 | Olympiakos Piraeus II | - | Apollon Lárissa | 0:1 (0:0) | |
| 16:00 | Veria FC | - | PAOK Saloniki II | 2:1 (1:0) | ||
| 27.02.2022 | 13:45 | Pierikos Katerini | - | Almopos Arideas | 2:2 (1:2) | |
| 13:45 | Anagennisi Karditsa | - | Niki Volou FC | 0:0 (0:0) | ||
| 13:45 | AEP Iraklis FC | - | AO Trikala | 0:1 (0:1) | ||
| 13:45 | Panserraikos | - | AE Lárissa | 0:1 (0:1) | ||
| 28.02.2022 | 16:00 | Xanthi FC | - | AO Kavala | 0:0 (0:0) | |
| 23.03.2022 | 14:00 | Apollon Pontou | - | Olympiakos Volou | 1:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 20 | 15 | 3 | 2 | 44:16 | 28 | 48 |
| 2 |
|
AE Lárissa | 19 | 12 | 6 | 1 | 26:6 | 20 | 42 |
| 3 |
|
Anagennisi Karditsa | 20 | 10 | 5 | 5 | 30:18 | 12 | 35 |
| 4 |
|
Xanthi FC | 19 | 9 | 7 | 3 | 28:12 | 16 | 34 |
| 5 |
|
AEP Iraklis FC | 20 | 6 | 11 | 3 | 22:13 | 9 | 29 |
| 6 |
|
PAOK Saloniki II | 20 | 7 | 8 | 5 | 25:19 | 6 | 29 |
| 7 |
|
Niki Volou FC | 20 | 7 | 7 | 6 | 22:14 | 8 | 28 |
| 8 |
|
Olympiakos Piraeus II | 20 | 7 | 7 | 6 | 23:21 | 2 | 28 |
| 9 |
|
Almopos Arideas | 20 | 7 | 5 | 8 | 26:22 | 4 | 26 |
| 10 |
|
Thesprotos | 19 | 6 | 5 | 8 | 24:20 | 4 | 23 |
| 11 |
|
Apollon Pontou | 20 | 5 | 6 | 9 | 22:29 | -7 | 21 |
| 12 |
|
AO Trikala | 20 | 5 | 5 | 10 | 15:29 | -14 | 20 |
| 13 |
|
Pierikos Katerini | 20 | 4 | 7 | 9 | 20:29 | -9 | 19 |
| 14 |
|
Apollon Lárissa | 19 | 4 | 7 | 8 | 14:25 | -11 | 19 |
| 15 |
|
Panserraikos | 20 | 3 | 8 | 9 | 20:30 | -10 | 17 |
| 16 |
|
AO Kavala | 20 | 4 | 5 | 11 | 15:60 | -45 | 17 |
| 17 |
|
Olympiakos Volou | 20 | 4 | 4 | 12 | 22:35 | -13 | 16 |
| Play-off | |
| Relégation |
