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| 20.12.2011 | 13:00 | Agrotikos Asteras | - | Panathinaikos | 0:1 (0:1) | |
| 14:00 | AEL Kalloni | - | Panionios GSS | 2:3 (2:1, 2:2) ap | ||
| 16:00 | Pontion Katerinis | - | Skoda Xanthi | 0:2 (0:1) | ||
| 17:00 | Thrasyvoulos Fylis | - | Levadiakos | 4:2 (0:0, 1:1, 1:1) tab | ||
| 21.12.2011 | 13:00 | AO Proodeftiki | - | Asteras Tripolis | 0:5 (0:0) | |
| 13:00 | Anagennisi Epanomi | - | Atromitos | 2:3 (1:2) | ||
| 14:30 | Panserraikos | - | Ergotelis | 1:0 (0:0, 0:0) ap | ||
| 15:00 | GS Kallithea | - | Doxa Dramas FC | 0:1 (0:0) | ||
| 15:00 | Platanias Chanion | - | AO Kerkyra | 0:3 (0:2) | ||
| 15:00 | Ethnikos Asteras | - | PAOK Saloniki | 0:3 | ||
| 16:00 | Pierikos Katerini | - | Olympiakos Piraeus | 1:3 (1:2) | ||
| 17:00 | AE Lárissa | - | Panetolikos | 9:10 (0:0, 0:0, 0:0) tab | ||
| 22.12.2011 | 13:00 | Diagoras FC | - | PAS Giannina | 0:1 (0:1) | |
| 14:00 | PS Kalamata | - | AEK Athen | 0:1 (0:0) | ||
| 15:00 | Panachaiki GE | - | OFI Heraklion | 0:1 (0:0, 0:0) ap | ||
| 18:00 | Panthrakikos | - | Aris Saloniki | 1:2 (1:0) |
