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| 12.03.2022 | 17:00 | Étoile FC | - | Louhans-Cuiseaux | 2:1 (1:0) | |
| 17:00 | GFA Rumilly Vallières | - | Lyon-La Duchère | 1:0 (1:0) | ||
| 18:00 | Aubagne FC | - | Olympique Lyonnais B | 3:0 (1:0) | ||
| 18:00 | FC Martigues | - | AS Monaco B | 1:2 (1:2) | ||
| 18:00 | GOAL FC | - | RC Grasse | 0:0 (0:0) | ||
| 18:00 | Jura Sud | - | Marignane Gignac FC | 2:0 (1:0) | ||
| 18:00 | AS Saint-Priest | - | Hyères FC | 0:1 (0:1) | ||
| 18:00 | SC Toulon | - | Olympique Marseille B | 4:1 (2:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
GOAL FC | 21 | 13 | 6 | 2 | 38:13 | 25 | 45 |
| 2 |
|
FC Martigues | 21 | 9 | 8 | 4 | 27:20 | 7 | 35 |
| 3 |
|
Aubagne FC | 21 | 9 | 7 | 5 | 28:19 | 9 | 34 |
| 4 |
|
RC Grasse | 21 | 8 | 8 | 5 | 22:19 | 3 | 32 |
| 5 |
|
Louhans-Cuiseaux | 21 | 8 | 7 | 6 | 26:20 | 6 | 31 |
| 6 |
|
Étoile FC | 21 | 8 | 7 | 6 | 22:18 | 4 | 31 |
| 7 |
|
Marignane Gignac FC | 21 | 8 | 5 | 8 | 20:19 | 1 | 29 |
| 8 |
|
Jura Sud | 21 | 8 | 5 | 8 | 26:29 | -3 | 29 |
| 9 |
|
Olympique Lyonnais B | 21 | 7 | 7 | 7 | 20:25 | -5 | 28 |
| 10 |
|
SC Toulon | 21 | 6 | 9 | 6 | 20:18 | 2 | 27 |
| 11 |
|
Hyères FC | 21 | 6 | 8 | 7 | 21:23 | -2 | 26 |
| 12 |
|
AS Monaco B | 21 | 6 | 6 | 9 | 21:27 | -6 | 24 |
| 13 |
|
Lyon-La Duchère | 21 | 5 | 8 | 8 | 22:26 | -4 | 23 |
| 14 |
|
GFA Rumilly Vallières | 21 | 5 | 6 | 10 | 15:26 | -11 | 21 |
| 15 |
|
AS Saint-Priest | 21 | 5 | 4 | 12 | 22:31 | -9 | 19 |
| 16 |
|
Olympique Marseille B | 21 | 5 | 3 | 13 | 20:37 | -17 | 18 |
| Promotion | |
| Relégation |
