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| 05.03.2022 | 16:00 | Olympique Lyonnais B | - | GOAL FC | 0:2 (0:1) | |
| 18:00 | AS Monaco B | - | SC Toulon | 0:1 (0:0) | ||
| 18:00 | Hyères FC | - | GFA Rumilly Vallières | 1:0 (0:0) | ||
| 18:00 | RC Grasse | - | Étoile FC | 1:2 (1:1) | ||
| 18:00 | Louhans-Cuiseaux | - | AS Saint-Priest | 0:1 (0:1) | ||
| 18:00 | Lyon-La Duchère | - | FC Martigues | 2:2 (1:1) | ||
| 18:00 | Olympique Marseille B | - | Jura Sud | 3:0 (2:0) | ||
| 18:00 | Marignane Gignac FC | - | Aubagne FC | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
GOAL FC | 20 | 13 | 5 | 2 | 38:13 | 25 | 44 |
| 2 |
|
FC Martigues | 20 | 9 | 8 | 3 | 26:18 | 8 | 35 |
| 3 |
|
Louhans-Cuiseaux | 20 | 8 | 7 | 5 | 25:18 | 7 | 31 |
| 4 |
|
Aubagne FC | 20 | 8 | 7 | 5 | 25:19 | 6 | 31 |
| 5 |
|
RC Grasse | 20 | 8 | 7 | 5 | 22:19 | 3 | 31 |
| 6 |
|
Marignane Gignac FC | 20 | 8 | 5 | 7 | 20:17 | 3 | 29 |
| 7 |
|
Étoile FC | 20 | 7 | 7 | 6 | 20:17 | 3 | 28 |
| 8 |
|
Olympique Lyonnais B | 20 | 7 | 7 | 6 | 20:22 | -2 | 28 |
| 9 |
|
Jura Sud | 20 | 7 | 5 | 8 | 24:29 | -5 | 26 |
| 10 |
|
SC Toulon | 20 | 5 | 9 | 6 | 16:17 | -1 | 24 |
| 11 |
|
Lyon-La Duchère | 20 | 5 | 8 | 7 | 22:25 | -3 | 23 |
| 12 |
|
Hyères FC | 20 | 5 | 8 | 7 | 20:23 | -3 | 23 |
| 13 |
|
AS Monaco B | 20 | 5 | 6 | 9 | 19:26 | -7 | 21 |
| 14 |
|
AS Saint-Priest | 20 | 5 | 4 | 11 | 22:30 | -8 | 19 |
| 15 |
|
Olympique Marseille B | 20 | 5 | 3 | 12 | 19:33 | -14 | 18 |
| 16 |
|
GFA Rumilly Vallières | 20 | 4 | 6 | 10 | 14:26 | -12 | 18 |
| Promotion | |
| Relégation |
