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| 22.01.2022 | 16:00 | Jura Sud | - | Étoile FC | 1:0 (1:0) | |
| 18:00 | RC Grasse | - | AS Monaco B | 0:0 (0:0) | ||
| 18:00 | Louhans-Cuiseaux | - | Lyon-La Duchère | 1:0 (0:0) | ||
| 18:00 | Olympique Lyonnais B | - | FC Martigues | 0:1 (0:1) | ||
| 18:00 | Olympique Marseille B | - | AS Saint-Priest | 0:5 (0:3) | ||
| 18:00 | Marignane Gignac FC | - | GFA Rumilly Vallières | 2:0 (2:0) | ||
| 09.02.2022 | 20:00 | Aubagne FC | - | GOAL FC | 1:1 (0:1) | |
| 16.02.2022 | 20:00 | Hyères FC | - | SC Toulon | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
GOAL FC | 16 | 9 | 5 | 2 | 30:11 | 19 | 32 |
| 2 |
|
Aubagne FC | 16 | 8 | 5 | 3 | 24:16 | 8 | 29 |
| 3 |
|
RC Grasse | 16 | 8 | 5 | 3 | 17:11 | 6 | 29 |
| 4 |
|
Louhans-Cuiseaux | 16 | 7 | 6 | 3 | 21:14 | 7 | 27 |
| 5 |
|
Olympique Lyonnais B | 16 | 7 | 5 | 4 | 20:18 | 2 | 26 |
| 6 |
|
FC Martigues | 16 | 6 | 7 | 3 | 17:15 | 2 | 25 |
| 7 |
|
Marignane Gignac FC | 16 | 7 | 3 | 6 | 19:16 | 3 | 24 |
| 8 |
|
Jura Sud | 16 | 6 | 5 | 5 | 22:22 | 0 | 23 |
| 9 |
|
Étoile FC | 16 | 5 | 6 | 5 | 15:14 | 1 | 21 |
| 10 |
|
AS Monaco B | 16 | 5 | 4 | 7 | 15:19 | -4 | 19 |
| 11 |
|
Lyon-La Duchère | 16 | 4 | 5 | 7 | 15:20 | -5 | 17 |
| 12 |
|
SC Toulon | 16 | 3 | 8 | 5 | 13:14 | -1 | 17 |
| 13 |
|
Hyères FC | 16 | 3 | 7 | 6 | 14:18 | -4 | 16 |
| 14 |
|
GFA Rumilly Vallières | 16 | 4 | 4 | 8 | 13:21 | -8 | 16 |
| 15 |
|
AS Saint-Priest | 16 | 4 | 1 | 11 | 18:27 | -9 | 13 |
| 16 |
|
Olympique Marseille B | 16 | 3 | 2 | 11 | 11:28 | -17 | 11 |
| Promotion | |
| Relégation |
