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| 06.11.2021 | 16:00 | AS Monaco B | - | GOAL FC | 0:2 (0:2) | |
| 16:00 | Olympique Lyonnais B | - | SC Toulon | 0:0 (0:0) | ||
| 18:00 | Hyères FC | - | Jura Sud | 2:2 (1:0) | ||
| 18:00 | FC Martigues | - | Étoile FC | 0:3 (0:1) | ||
| 18:00 | GFA Rumilly Vallières | - | AS Saint-Priest | 1:0 (1:0) | ||
| 18:00 | RC Grasse | - | Marignane Gignac FC | 2:0 (0:0) | ||
| 18:00 | Louhans-Cuiseaux | - | Olympique Marseille B | 0:1 (0:0) | ||
| 18:00 | Lyon-La Duchère | - | Aubagne FC | 1:1 (0:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
GOAL FC | 11 | 7 | 2 | 2 | 20:8 | 12 | 23 |
| 2 |
|
RC Grasse | 11 | 7 | 2 | 2 | 14:8 | 6 | 23 |
| 3 |
|
Aubagne FC | 11 | 6 | 2 | 3 | 18:14 | 4 | 20 |
| 4 |
|
Louhans-Cuiseaux | 11 | 5 | 4 | 2 | 15:9 | 6 | 19 |
| 5 |
|
Jura Sud | 11 | 4 | 4 | 3 | 15:11 | 4 | 16 |
| 6 |
|
Olympique Lyonnais B | 11 | 4 | 4 | 3 | 14:14 | 0 | 16 |
| 7 |
|
SC Toulon | 11 | 3 | 6 | 2 | 11:9 | 2 | 15 |
| 8 |
|
GFA Rumilly Vallières | 11 | 4 | 3 | 4 | 12:13 | -1 | 15 |
| 9 |
|
FC Martigues | 11 | 3 | 5 | 3 | 9:13 | -4 | 14 |
| 10 |
|
AS Monaco B | 11 | 4 | 2 | 5 | 12:13 | -1 | 14 |
| 11 |
|
Étoile FC | 11 | 3 | 4 | 4 | 11:12 | -1 | 13 |
| 12 |
|
Lyon-La Duchère | 11 | 3 | 3 | 5 | 10:14 | -4 | 12 |
| 13 |
|
Marignane Gignac FC | 11 | 3 | 2 | 6 | 10:14 | -4 | 11 |
| 14 |
|
Hyères FC | 11 | 2 | 5 | 4 | 8:12 | -4 | 11 |
| 15 |
|
Olympique Marseille B | 11 | 3 | 1 | 7 | 10:17 | -7 | 10 |
| 16 |
|
AS Saint-Priest | 11 | 2 | 1 | 8 | 10:18 | -8 | 7 |
| Promotion | |
| Relégation |
