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| 12.02.2022 | 18:00 | Blois Foot 41 | - | St-Pryvé St-Hilaire | 2:1 (2:0) | |
| 18:00 | C'Chartres Football | - | AS Vitré | 5:2 (3:2) | ||
| 18:00 | EA Guingamp B | - | US Saint-Malo | 0:0 (0:0) | ||
| 18:00 | US Granvillaise | - | SM Caen B | 1:1 (0:0) | ||
| 18:00 | Châteaubriant Voltigeurs | - | FC Rouen 1899 | 0:1 (0:1) | ||
| 18:30 | Vannes OC | - | SO Romorantin | 3:1 (2:0) | ||
| 19:00 | FC Lorient B | - | Stade Plabennec | 1:0 (0:0) | ||
| 13.02.2022 | 15:00 | AS Poissy | - | FC Versailles | 0:3 (0:2) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Versailles | 18 | 10 | 7 | 1 | 27:11 | 16 | 37 |
| 2 |
|
FC Lorient B | 18 | 10 | 5 | 3 | 26:13 | 13 | 35 |
| 3 |
|
C'Chartres Football | 18 | 10 | 2 | 6 | 32:21 | 11 | 32 |
| 4 |
|
Blois Foot 41 | 18 | 8 | 6 | 4 | 26:28 | -2 | 30 |
| 5 |
|
St-Pryvé St-Hilaire | 18 | 8 | 4 | 6 | 23:19 | 4 | 28 |
| 6 |
|
Châteaubriant Voltigeurs | 18 | 8 | 4 | 6 | 23:19 | 4 | 28 |
| 7 |
|
Vannes OC | 18 | 7 | 6 | 5 | 26:22 | 4 | 27 |
| 8 |
|
EA Guingamp B | 18 | 6 | 6 | 6 | 22:27 | -5 | 24 |
| 9 |
|
SM Caen B | 18 | 6 | 6 | 6 | 19:22 | -3 | 24 |
| 10 |
|
FC Rouen 1899 | 18 | 5 | 7 | 6 | 19:18 | 1 | 22 |
| 11 |
|
AS Poissy | 18 | 3 | 10 | 5 | 18:20 | -2 | 19 |
| 12 |
|
US Granvillaise | 18 | 3 | 10 | 5 | 17:19 | -2 | 19 |
| 13 |
|
SO Romorantin | 18 | 5 | 4 | 9 | 17:27 | -10 | 19 |
| 14 |
|
US Saint-Malo | 18 | 4 | 5 | 9 | 11:21 | -10 | 17 |
| 15 |
|
AS Vitré | 18 | 3 | 5 | 10 | 18:26 | -8 | 14 |
| 16 |
|
Stade Plabennec | 18 | 2 | 5 | 11 | 14:25 | -11 | 11 |
| Promotion | |
| Relégation |
