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| 15.03.2022 | 19:00 | AS Nancy Lorraine | - | Paris FC | 3:0 (3:0) | |
| 19:00 | Dijon FCO | - | Havre AC | 2:0 (0:0) | ||
| 19:00 | Chamois Niortais | - | FC Sochaux | 1:1 (0:1) | ||
| 19:00 | Pau FC | - | Grenoble Foot 38 | 0:1 (0:1) | ||
| 19:00 | Toulouse FC | - | Amiens SC | 6:0 (3:0) | ||
| 19:00 | Valenciennes FC | - | SM Caen | 1:1 (1:1) | ||
| 19:00 | Nîmes Olympique | - | AJ Auxerre | 1:2 (1:2) | ||
| 19:00 | Rodez AF | - | EA Guingamp | 1:1 (0:1) | ||
| 19:00 | SC Bastia | - | USL Dunkerque | 1:0 (1:0) | ||
| 19:00 | US Quevilly-Rouen | - | AC Ajaccio | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Toulouse FC | 29 | 17 | 9 | 3 | 67:25 | 42 | 60 |
| 2 |
|
Paris FC | 29 | 16 | 7 | 6 | 42:26 | 16 | 55 |
| 3 |
|
AJ Auxerre | 29 | 15 | 9 | 5 | 46:31 | 15 | 54 |
| 4 |
|
AC Ajaccio | 29 | 15 | 7 | 7 | 25:15 | 10 | 52 |
| 5 |
|
FC Sochaux | 29 | 13 | 9 | 7 | 33:28 | 5 | 48 |
| 6 |
|
Havre AC | 29 | 10 | 11 | 8 | 27:27 | 0 | 41 |
| 7 |
|
Nîmes Olympique | 29 | 11 | 6 | 12 | 35:38 | -3 | 39 |
| 8 |
|
Pau FC | 29 | 11 | 5 | 13 | 29:32 | -3 | 38 |
| 9 |
|
Dijon FCO | 29 | 11 | 4 | 14 | 33:36 | -3 | 37 |
| 10 |
|
SM Caen | 29 | 9 | 9 | 11 | 38:32 | 6 | 36 |
| 11 |
|
Amiens SC | 29 | 8 | 12 | 9 | 36:32 | 4 | 36 |
| 12 |
|
SC Bastia | 29 | 8 | 12 | 9 | 29:27 | 2 | 36 |
| 13 |
|
Chamois Niortais | 29 | 10 | 6 | 13 | 29:31 | -2 | 36 |
| 14 |
|
EA Guingamp | 29 | 8 | 12 | 9 | 30:36 | -6 | 36 |
| 15 |
|
Valenciennes FC | 29 | 7 | 12 | 10 | 28:37 | -9 | 33 |
| 16 |
|
Rodez AF | 29 | 7 | 11 | 11 | 24:32 | -8 | 32 |
| 17 |
|
Grenoble Foot 38 | 29 | 9 | 5 | 15 | 22:36 | -14 | 32 |
| 18 |
|
US Quevilly-Rouen | 29 | 7 | 10 | 12 | 24:38 | -14 | 31 |
| 19 |
|
USL Dunkerque | 29 | 8 | 6 | 15 | 22:35 | -13 | 30 |
| 20 |
|
AS Nancy Lorraine | 29 | 5 | 8 | 16 | 24:49 | -25 | 23 |
| Promotion | |
| Play-off | |
| Relégation | |
| Relégation |
