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| 12.01.2010 | 20:00 | CS Sedan | - | Clermont Foot Auvergne 63 | 1:0 (0:0) | |
| 13.01.2010 | 17:00 | EA Guingamp | - | Paris Saint-Germain | 1:0 (0:0) | |
| 18:45 | Olympique Lyonnais | - | FC Metz | 3:0 (1:0) | ||
| 19:00 | RC Lens | - | FC Lorient | 1:2 (0:2) | ||
| 19:00 | Toulouse FC | - | AS Nancy Lorraine | 3:0 (2:0) | ||
| 19:00 | Lille OSC | - | Stade Rennais | 3:1 (1:0, 1:1) ap | ||
| 20:45 | AS Saint-Étienne | - | Olympique Marseille | 2:3 (2:1) | ||
| 26.01.2010 | 20:45 | Le Mans UC 72 | - | Girondins Bordeaux | 2:3 (2:2) |
