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| 05.01.2001 | 18:00 | Stade Rennais | - | FC Nantes | 2:4 (0:1, 1:1) ap | |
| 20:30 | AS Cannes | - | ASOA Valence | 1:2 (0:1) | ||
| 06.01.2001 | 15:15 | Havre AC | - | Olympique Marseille | 4:1 (1:0) | |
| 15:30 | Girondins Bordeaux | - | Lille OSC | 1:0 (0:0) | ||
| 18:00 | AJ Auxerre | - | AS Red Star 93 | 2:0 (0:0) | ||
| 18:00 | Toulouse FC | - | Chamois Niortais | 0:1 (0:0) | ||
| 18:00 | AC Ajaccio | - | AS Saint-Étienne | 1:2 (0:0, 0:0) ap | ||
| 18:00 | EA Guingamp | - | Amiens SC | 1:3 (0:0) | ||
| 20:45 | CS Sedan | - | Olympique Lyonnais | 1:2 (0:1) | ||
| 07.01.2001 | 15:00 | AS Nancy Lorraine | - | Paris Saint-Germain | 3:1 (1:0) | |
| 18:00 | RC Strasbourg | - | LB Châteauroux | 2:4 (1:0, 2:2) ap | ||
| 18:00 | ES Wasquehal | - | FC Metz | 3:1 (0:0) | ||
| 18:00 | AS Monaco | - | FC Gueugnon | 2:0 (2:0) | ||
| 18:00 | ESTAC Troyes | - | US Créteil-Lusitanos | 3:0 (2:0) | ||
| 18:00 | RC Lens | - | Nîmes Olympique | 4:0 (1:0) | ||
| 20:00 | SC Bastia | - | OGC Nice | 2:1 (1:0) |
