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| 06.02.2022 | 14:30 | SM Caen | - | Paris FC | 1:1 (0:0) | |
| 14:30 | AS Vitré | - | Montrouge FC | 2:3 (1:1) | ||
| 14:30 | Le Mans FC | - | US Orléans | 3:1 (2:1) | ||
| 14:30 | Paris Saint-Germain | - | Tours FC | 9:1 (3:1) | ||
| 14:30 | Blois Foot 41 | - | CS Brétigny | 7:5 (2:1) | ||
| 14:30 | Havre AC | - | FC Mantois | 1:1 (1:0) | ||
| 16:30 | FC Rouen 1899 | - | US Avranches | 2:2 (1:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Paris Saint-Germain | 16 | 12 | 3 | 1 | 55:18 | 37 | 39 |
| 2 |
|
Paris FC | 16 | 9 | 3 | 4 | 36:22 | 14 | 30 |
| 3 |
|
Montrouge FC | 16 | 8 | 5 | 3 | 24:18 | 6 | 29 |
| 4 |
|
US Orléans | 16 | 8 | 3 | 5 | 36:28 | 8 | 27 |
| 5 |
|
US Avranches | 16 | 8 | 2 | 6 | 31:27 | 4 | 26 |
| 6 |
|
Havre AC | 16 | 7 | 4 | 5 | 37:22 | 15 | 25 |
| 7 |
|
SM Caen | 16 | 7 | 4 | 5 | 30:23 | 7 | 25 |
| 8 |
|
CS Brétigny | 16 | 6 | 4 | 6 | 30:37 | -7 | 22 |
| 9 |
|
FC Mantois | 16 | 5 | 5 | 6 | 19:18 | 1 | 20 |
| 10 |
|
FC Rouen 1899 | 16 | 4 | 5 | 7 | 32:32 | 0 | 17 |
| 11 |
|
AS Vitré | 16 | 5 | 0 | 11 | 19:56 | -37 | 15 |
| 12 |
|
Le Mans FC | 16 | 4 | 2 | 10 | 22:35 | -13 | 14 |
| 13 |
|
Tours FC | 16 | 4 | 2 | 10 | 19:40 | -21 | 14 |
| 14 |
|
Blois Foot 41 | 16 | 2 | 4 | 10 | 21:35 | -14 | 10 |
| Relégation |
