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| 01.05.2022 | 15:00 | FC Istres | - | AS Saint-Étienne | 0:1 (0:1) | |
| 15:00 | Toulouse FC | - | Pieve di Lota | 12:0 (4:0) | ||
| 15:00 | OGC Nice | - | AS Monaco | 3:5 (1:2) | ||
| 15:00 | AS Cannes | - | US Colomiers | 0:2 (0:0) | ||
| 15:00 | Olympique Marseille | - | AC Ajaccio | 1:2 (1:1) | ||
| 15:00 | SC Toulon | - | Nîmes Olympique | 2:1 (2:0) | ||
| 15:00 | AS Béziers | - | Montpellier HSC | 0:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AS Monaco | 25 | 18 | 4 | 3 | 87:24 | 63 | 58 |
| 2 |
|
Toulouse FC | 25 | 16 | 3 | 6 | 57:20 | 37 | 51 |
| 3 |
|
AS Saint-Étienne | 25 | 14 | 7 | 4 | 63:27 | 36 | 49 |
| 4 |
|
Montpellier HSC | 25 | 14 | 4 | 7 | 42:29 | 13 | 46 |
| 5 |
|
OGC Nice | 25 | 12 | 7 | 6 | 55:34 | 21 | 43 |
| 6 |
|
AC Ajaccio | 25 | 12 | 3 | 10 | 46:33 | 13 | 39 |
| 7 |
|
Olympique Marseille | 25 | 11 | 5 | 9 | 53:34 | 19 | 38 |
| 8 |
|
US Colomiers | 25 | 9 | 9 | 7 | 33:27 | 6 | 36 |
| 9 |
|
AS Cannes | 25 | 10 | 3 | 12 | 58:43 | 15 | 33 |
| 10 |
|
AS Béziers | 25 | 9 | 6 | 10 | 43:34 | 9 | 33 |
| 11 |
|
FC Istres | 25 | 9 | 3 | 13 | 34:36 | -2 | 30 |
| 12 |
|
SC Toulon | 25 | 8 | 3 | 14 | 38:42 | -4 | 27 |
| 13 |
|
Nîmes Olympique | 25 | 3 | 3 | 19 | 24:61 | -37 | 12 |
| 14 |
|
Pieve di Lota | 25 | 0 | 0 | 25 | 6:195 | -189 | 0 |
| Play-off | |
| Relégation |
