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| 07.01.2023 | 13:00 | Recreativo Granada | - | CD San Roque de Lepe | 1:0 (1:0) | |
| 18:00 | Sevilla Atlético | - | Juventud Torremolinos | 1:0 (1:0) | ||
| 08.01.2023 | 11:00 | FC Cartagena B | - | Yeclano Deportivo | 0:0 (0:0) | |
| 12:00 | Utrera CD | - | Cádiz CF B | 2:1 (2:0) | ||
| 12:00 | Recreativo Huelva | - | Atlético Mancha Real | 4:0 (2:0) | ||
| 17:00 | Antequera CF | - | Atlético Sanluqueño CF | 2:0 (0:0) | ||
| 17:00 | CD El Ejido 2012 | - | Real Betis B | 1:0 (1:0) | ||
| 17:00 | Mar Menor CF | - | UCAM Murcia CF | 0:0 (0:0) | ||
| 17:00 | Xerez DFC | - | Vélez CF | 2:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Antequera CF | 16 | 12 | 3 | 1 | 32:13 | 19 | 39 |
| 2 |
|
Recreativo Huelva | 16 | 9 | 4 | 3 | 23:15 | 8 | 31 |
| 3 |
|
Yeclano Deportivo | 16 | 7 | 6 | 3 | 18:13 | 5 | 27 |
| 4 |
|
Atlético Sanluqueño CF | 16 | 7 | 5 | 4 | 21:16 | 5 | 26 |
| 5 |
|
Mar Menor CF | 16 | 6 | 6 | 4 | 19:16 | 3 | 24 |
| 6 |
|
FC Cartagena B | 16 | 7 | 3 | 6 | 18:19 | -1 | 24 |
| 7 |
|
UCAM Murcia CF | 16 | 5 | 6 | 5 | 23:19 | 4 | 21 |
| 8 |
|
Recreativo Granada | 16 | 6 | 3 | 7 | 20:20 | 0 | 21 |
| 9 |
|
Real Betis B | 16 | 5 | 6 | 5 | 14:15 | -1 | 21 |
|
Xerez DFC | 16 | 5 | 6 | 5 | 14:15 | -1 | 21 | |
| 11 |
|
Vélez CF | 16 | 6 | 3 | 7 | 17:20 | -3 | 21 |
| 12 |
|
Cádiz CF B | 16 | 5 | 5 | 6 | 19:19 | 0 | 20 |
| 13 |
|
Atlético Mancha Real | 16 | 5 | 4 | 7 | 12:20 | -8 | 19 |
| 14 |
|
CD El Ejido 2012 | 16 | 5 | 3 | 8 | 11:15 | -4 | 18 |
| 15 |
|
CD San Roque de Lepe | 16 | 4 | 4 | 8 | 17:19 | -2 | 16 |
| 16 |
|
Utrera CD | 16 | 4 | 3 | 9 | 14:28 | -14 | 15 |
| 17 |
|
Juventud Torremolinos | 16 | 2 | 8 | 6 | 12:18 | -6 | 14 |
| 18 |
|
Sevilla Atlético | 16 | 4 | 2 | 10 | 17:21 | -4 | 14 |
| Promotion | |
| Play-off | |
| Relégation |
