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| 12.02.2021 | 21:00 | CE Sabadell | - | Real Zaragoza | 1:1 (0:1) | |
| 13.02.2021 | 16:00 | FC Cartagena | - | Rayo Vallecano | 2:2 (1:1) | |
| 18:15 | CD Mirandés | - | Girona FC | 3:3 (2:1) | ||
| 20:30 | CD Tenerife | - | SD Ponferradina | 1:0 (0:0) | ||
| 14.02.2021 | 14:00 | RCD Mallorca | - | Espanyol Barcelona | 1:2 (0:1) | |
| 16:00 | UD Almería | - | UD Las Palmas | 3:1 (1:0) | ||
| 18:15 | AD Alcorcón | - | UD Logroñés | 1:0 (1:0) | ||
| 18:15 | CD Leganés | - | Albacete | 3:1 (2:0) | ||
| 21:00 | Sporting Gijón | - | Málaga CF | 1:0 (0:0) | ||
| 15.02.2021 | 19:00 | CD Castellón | - | CF Fuenlabrada | 1:2 (1:2) | |
| 21:00 | Real Oviedo | - | CD Lugo | 3:1 (1:1) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
RCD Mallorca | 25 | 15 | 6 | 4 | 34:13 | 21 | 51 |
| 2 |
|
Espanyol Barcelona | 25 | 15 | 4 | 6 | 37:16 | 21 | 49 |
| 3 |
|
UD Almería | 25 | 15 | 4 | 6 | 38:22 | 16 | 49 |
| 4 |
|
CD Leganés | 25 | 14 | 4 | 7 | 30:20 | 10 | 46 |
| 5 |
|
Sporting Gijón | 25 | 12 | 7 | 6 | 26:17 | 9 | 43 |
| 6 |
|
Rayo Vallecano | 25 | 12 | 5 | 8 | 30:23 | 7 | 41 |
| 7 |
|
CD Mirandés | 25 | 10 | 7 | 8 | 26:21 | 5 | 37 |
| 8 |
|
SD Ponferradina | 25 | 11 | 4 | 10 | 26:27 | -1 | 37 |
| 9 |
|
Girona FC | 25 | 9 | 7 | 9 | 20:23 | -3 | 34 |
| 10 |
|
CD Tenerife | 25 | 9 | 6 | 10 | 22:23 | -1 | 33 |
| 11 |
|
CF Fuenlabrada | 25 | 7 | 12 | 6 | 26:26 | 0 | 33 |
| 12 |
|
UD Las Palmas | 25 | 8 | 8 | 9 | 25:32 | -7 | 32 |
| 13 |
|
CD Lugo | 25 | 8 | 8 | 9 | 25:26 | -1 | 32 |
| 14 |
|
Real Oviedo | 25 | 7 | 10 | 8 | 28:26 | 2 | 31 |
| 15 |
|
Málaga CF | 25 | 8 | 7 | 10 | 22:32 | -10 | 31 |
| 16 |
|
UD Logroñés | 25 | 8 | 5 | 12 | 18:31 | -13 | 29 |
| 17 |
|
Real Zaragoza | 25 | 7 | 6 | 12 | 21:24 | -3 | 27 |
| 18 |
|
CE Sabadell | 25 | 6 | 8 | 11 | 23:29 | -6 | 26 |
| 19 |
|
FC Cartagena | 25 | 6 | 7 | 12 | 27:35 | -8 | 25 |
| 20 |
|
Albacete | 25 | 6 | 6 | 13 | 17:31 | -14 | 24 |
| 21 |
|
AD Alcorcón | 25 | 6 | 5 | 14 | 14:26 | -12 | 23 |
| 22 |
|
CD Castellón | 25 | 6 | 4 | 15 | 22:34 | -12 | 22 |
| Promotion | |
| Play-off | |
| Relégation |
