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| 14.01.2018 | 12:00 | Extremadura UD | - | Lorca Deportiva | 0:2 (0:0) | |
| 12:00 | Real Betis B | - | RB Linense | 3:2 (1:0) | ||
| 12:00 | FC Jumilla | - | UD Melilla | 0:2 (0:0) | ||
| 12:00 | Granada CF B | - | CF Villanovense | 3:1 (2:0) | ||
| 12:00 | Marbella FC | - | Córdoba CF B | 4:1 (2:1) | ||
| 13:00 | UD Las Palmas B | - | UCAM Murcia CF | 2:0 (1:0) | ||
| 17:00 | CD Badajoz | - | Écija Balompié | 3:0 (1:0) | ||
| 17:00 | FC Cartagena | - | CD El Ejido 2012 | 3:0 (1:0) | ||
| 17:00 | San Fernando CD | - | Mérida AD | 1:0 (1:0) | ||
| 18:00 | Real Murcia | - | Recreativo Huelva | 0:0 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Cartagena | 21 | 12 | 6 | 3 | 31:20 | 11 | 42 |
| 2 |
|
Extremadura UD | 21 | 11 | 5 | 5 | 34:19 | 15 | 38 |
| 3 |
|
Marbella FC | 21 | 11 | 4 | 6 | 29:19 | 10 | 37 |
| 4 |
|
UCAM Murcia CF | 21 | 10 | 6 | 5 | 22:19 | 3 | 36 |
| 5 |
|
Real Murcia | 21 | 9 | 7 | 5 | 27:18 | 9 | 34 |
| 6 |
|
Granada CF B | 21 | 8 | 7 | 6 | 21:18 | 3 | 31 |
| 7 |
|
UD Melilla | 21 | 9 | 4 | 8 | 19:13 | 6 | 31 |
| 8 |
|
CD El Ejido 2012 | 21 | 7 | 8 | 6 | 33:30 | 3 | 29 |
| 9 |
|
RB Linense | 21 | 7 | 7 | 7 | 28:22 | 6 | 28 |
| 10 |
|
San Fernando CD | 21 | 7 | 6 | 8 | 26:26 | 0 | 27 |
| 11 |
|
CD Badajoz | 21 | 6 | 8 | 7 | 28:26 | 2 | 26 |
| 12 |
|
Mérida AD | 21 | 6 | 8 | 7 | 21:22 | -1 | 26 |
| 13 |
|
CF Villanovense | 21 | 6 | 8 | 7 | 16:22 | -6 | 26 |
| 14 |
|
Recreativo Huelva | 21 | 6 | 8 | 7 | 19:19 | 0 | 26 |
| 15 |
|
Écija Balompié | 21 | 6 | 7 | 8 | 22:31 | -9 | 25 |
| 16 |
|
Córdoba CF B | 21 | 5 | 8 | 8 | 28:29 | -1 | 23 |
| 17 |
|
Real Betis B | 21 | 5 | 7 | 9 | 25:36 | -11 | 22 |
| 18 |
|
FC Jumilla | 21 | 4 | 8 | 9 | 17:29 | -12 | 20 |
| 19 |
|
UD Las Palmas B | 21 | 5 | 4 | 12 | 24:32 | -8 | 19 |
| 20 |
|
Lorca Deportiva | 21 | 4 | 6 | 11 | 20:40 | -20 | 18 |
| Play-off | |
| Play-off | |
| Relégation | |
| Relégation |
