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| 16.05.2021 | 18:30 | CD Alavés | - | Granada CF | 4:2 (2:1) | |
| 18:30 | Athletic Club | - | Real Madrid | 0:1 (0:0) | ||
| 18:30 | Atlético Madrid | - | CA Osasuna | 2:1 (0:0) | ||
| 18:30 | FC Barcelona | - | RC Celta | 1:2 (1:1) | ||
| 18:30 | Real Betis | - | SD Huesca | 1:0 (0:0) | ||
| 18:30 | Getafe CF | - | Levante UD | 2:1 (1:1) | ||
| 18:30 | Cádiz CF | - | Elche CF | 1:3 (1:0) | ||
| 18:30 | Real Sociedad | - | Real Valladolid | 4:1 (4:0) | ||
| 18:30 | Valencia CF | - | SD Eibar | 4:1 (3:1) | ||
| 18:30 | Villarreal CF | - | Sevilla FC | 4:0 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Madrid | 37 | 25 | 8 | 4 | 65:24 | 41 | 83 |
| 2 |
|
Real Madrid | 37 | 24 | 9 | 4 | 65:27 | 38 | 81 |
| 3 |
|
FC Barcelona | 37 | 23 | 7 | 7 | 84:38 | 46 | 76 |
| 4 |
|
Sevilla FC | 37 | 23 | 5 | 9 | 52:33 | 19 | 74 |
| 5 |
|
Real Sociedad | 37 | 16 | 11 | 10 | 58:38 | 20 | 59 |
| 6 |
|
Villarreal CF | 37 | 15 | 13 | 9 | 59:42 | 17 | 58 |
| 7 |
|
Real Betis | 37 | 16 | 10 | 11 | 47:48 | -1 | 58 |
| 8 |
|
RC Celta | 37 | 14 | 11 | 12 | 53:54 | -1 | 53 |
| 9 |
|
Athletic Club | 37 | 11 | 13 | 13 | 46:40 | 6 | 46 |
| 10 |
|
Granada CF | 37 | 13 | 6 | 18 | 47:65 | -18 | 45 |
| 11 |
|
CA Osasuna | 37 | 11 | 11 | 15 | 37:47 | -10 | 44 |
| 12 |
|
Cádiz CF | 37 | 11 | 10 | 16 | 34:56 | -22 | 43 |
| 13 |
|
Valencia CF | 37 | 10 | 12 | 15 | 50:53 | -3 | 42 |
| 14 |
|
Levante UD | 37 | 9 | 13 | 15 | 44:55 | -11 | 40 |
| 15 |
|
CD Alavés | 37 | 9 | 11 | 17 | 36:56 | -20 | 38 |
| 16 |
|
Getafe CF | 37 | 9 | 10 | 18 | 28:43 | -15 | 37 |
| 17 |
|
SD Huesca | 37 | 7 | 12 | 18 | 34:53 | -19 | 33 |
| 18 |
|
Elche CF | 37 | 7 | 12 | 18 | 32:55 | -23 | 33 |
| 19 |
|
Real Valladolid | 37 | 5 | 16 | 16 | 33:55 | -22 | 31 |
| 20 |
|
SD Eibar | 37 | 6 | 12 | 19 | 29:51 | -22 | 30 |
| Champions League | |
| Europa League | |
| Europa League Quali. | |
| Relégation |
