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| 01.03.2022 | 19:00 | Alhama CF | - | Real Madrid | 0:3 (0:1) | |
| 21:00 | Athletic Club | - | Sevilla FC | 0:1 (0:1) | ||
| 02.03.2022 | 14:00 | Valencia CF | - | UDG Tenerife Sur | 0:3 (0:2) | |
| 16:00 | Rayo Vallecano | - | FC Barcelona | 1:3 (0:2) | ||
| 18:00 | Villarreal CF | - | Real Sociedad | 1:2 (0:2) | ||
| 03.03.2022 | 15:00 | Real Betis | - | Levante UD | 1:4 (0:1) | |
| 17:00 | Espanyol Barcelona | - | Madrid CFF | 1:2 (0:0) | ||
| 19:00 | Sporting de Huelva | - | Atlético Madrid | 2:1 (1:0) |
