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| 15.01.2022 | 16:00 | RCD Mallorca | - | Espanyol Barcelona | 2:1 (1:0) | |
| 18:30 | Girona FC | - | Rayo Vallecano | 1:2 (1:1) | ||
| 18:30 | Sporting Gijón | - | Cádiz CF | 2:4 (0:0, 0:0, 0:0) tab | ||
| 16.01.2022 | 12:00 | Atlético Baleares | - | Valencia CF | 0:1 (0:1) | |
| 16:00 | Real Betis | - | Sevilla FC | 2:1 (1:1) | ||
| 19.01.2022 | 21:00 | Real Sociedad | - | Atlético Madrid | 2:0 (1:0) | |
| 20.01.2022 | 19:00 | Elche CF | - | Real Madrid | 1:2 (0:0, 0:0, 1:2) ap | |
| 21:30 | Athletic Club | - | FC Barcelona | 3:2 (1:1, 2:2) ap |
