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| 16.10.2018 | 20:00 | Elche CF | - | Córdoba CF | 1:4 (0:2) | |
| 17.10.2018 | 17:00 | CD Ebro | - | Lleida Esportiu | 2:1 (0:1) | |
| 20:00 | CD Lugo | - | AD Alcorcón | 1:0 (0:0) | ||
| 20:15 | UD Mutilvera | - | CF Villanovense | 1:3 (1:1) | ||
| 20:30 | UE Sant Andreu | - | CD Calahorra | 1:0 (0:0, 0:0) ap | ||
| 20:30 | Racing Santander | - | UD Logroñés | 1:0 (0:0) | ||
| 20:45 | UD Melilla | - | Ontinyent CF | 2:0 (0:0) | ||
| 20:45 | Lorca FC | - | Cultural Leonesa | 0:3 (0:1) | ||
| 21:00 | Real Zaragoza | - | Cádiz CF | 0:1 (0:0) | ||
| 18.10.2018 | 20:00 | Rayo Majadahonda | - | Sporting Gijón | 3:4 (0:1, 1:1, 1:1) tab | |
| 21:00 | UD Almería | - | CF Reus Deportiu | 3:1 (1:0) |
