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| 02.10.2021 | 13:30 | Manchester United | - | Everton FC | 1:1 (1:0) | |
| 16:00 | Burnley FC | - | Norwich City | 0:0 (0:0) | ||
| 16:00 | Chelsea FC | - | Southampton FC | 3:1 (1:0) | ||
| 16:00 | Leeds United | - | Watford FC | 1:0 (1:0) | ||
| 16:00 | Wolverhampton Wanderers | - | Newcastle United | 2:1 (1:1) | ||
| 18:30 | Brighton & Hove Albion | - | Arsenal FC | 0:0 (0:0) | ||
| 03.10.2021 | 15:00 | Crystal Palace | - | Leicester City | 2:2 (0:2) | |
| 15:00 | Tottenham Hotspur | - | Aston Villa | 2:1 (1:0) | ||
| 15:00 | West Ham United | - | Brentford FC | 1:2 (0:1) | ||
| 17:30 | Liverpool FC | - | Manchester City | 2:2 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Chelsea FC | 7 | 5 | 1 | 1 | 15:3 | 12 | 16 |
| 2 |
|
Liverpool FC | 7 | 4 | 3 | 0 | 17:6 | 11 | 15 |
| 3 |
|
Manchester City | 7 | 4 | 2 | 1 | 14:3 | 11 | 14 |
| 4 |
|
Manchester United | 7 | 4 | 2 | 1 | 14:6 | 8 | 14 |
| 5 |
|
Everton FC | 7 | 4 | 2 | 1 | 13:8 | 5 | 14 |
| 6 |
|
Brighton & Hove Albion | 7 | 4 | 2 | 1 | 8:5 | 3 | 14 |
| 7 |
|
Brentford FC | 7 | 3 | 3 | 1 | 10:6 | 4 | 12 |
| 8 |
|
Tottenham Hotspur | 7 | 4 | 0 | 3 | 6:10 | -4 | 12 |
| 9 |
|
West Ham United | 7 | 3 | 2 | 2 | 14:10 | 4 | 11 |
| 10 |
|
Aston Villa | 7 | 3 | 1 | 3 | 10:9 | 1 | 10 |
| 11 |
|
Arsenal FC | 7 | 3 | 1 | 3 | 5:10 | -5 | 10 |
| 12 |
|
Wolverhampton Wanderers | 7 | 3 | 0 | 4 | 5:6 | -1 | 9 |
| 13 |
|
Leicester City | 7 | 2 | 2 | 3 | 9:12 | -3 | 8 |
| 14 |
|
Crystal Palace | 7 | 1 | 4 | 2 | 8:11 | -3 | 7 |
| 15 |
|
Watford FC | 7 | 2 | 1 | 4 | 7:10 | -3 | 7 |
| 16 |
|
Leeds United | 7 | 1 | 3 | 3 | 7:14 | -7 | 6 |
| 17 |
|
Southampton FC | 7 | 0 | 4 | 3 | 5:10 | -5 | 4 |
| 18 |
|
Burnley FC | 7 | 0 | 3 | 4 | 5:11 | -6 | 3 |
| 19 |
|
Newcastle United | 7 | 0 | 3 | 4 | 8:16 | -8 | 3 |
| 20 |
|
Norwich City | 7 | 0 | 1 | 6 | 2:16 | -14 | 1 |
| Champions League | |
| Europa League | |
| Relégation |
