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| 17.09.2022 | 16:00 | Zbrojovka Brno | - | FK Teplice | 2:2 (2:2) | |
| 16:00 | Dynamo České Budějovice | - | Sigma Olomouc | 0:3 (0:2) | ||
| 16:00 | Slovan Liberec | - | FK Mladá Boleslav | 1:3 (1:0) | ||
| 19:00 | AC Sparta Praha | - | Baník Ostrava | 1:1 (1:0) | ||
| 18.09.2022 | 16:00 | 1. FC Slovácko | - | FK Jablonec | 0:2 (0:0) | |
| 16:00 | FC Hradec Králové | - | FC Trinity Zlín | 0:0 (0:0) | ||
| 16:00 | FK Pardubice | - | Bohemians Praha 1905 | 0:1 (0:0) | ||
| 19:00 | Viktoria Plzeň | - | Slavia Praha | 3:0 (2:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Viktoria Plzeň | 9 | 8 | 1 | 0 | 21:6 | 15 | 25 |
| 2 |
|
Slavia Praha | 9 | 6 | 1 | 2 | 31:9 | 22 | 19 |
| 3 |
|
AC Sparta Praha | 9 | 3 | 5 | 1 | 13:8 | 5 | 14 |
| 4 |
|
Slovan Liberec | 9 | 4 | 2 | 3 | 15:11 | 4 | 14 |
| 5 |
|
Bohemians Praha 1905 | 9 | 4 | 2 | 3 | 13:11 | 2 | 14 |
| 6 |
|
FC Hradec Králové | 9 | 4 | 2 | 3 | 7:8 | -1 | 14 |
| 7 |
|
Zbrojovka Brno | 9 | 4 | 2 | 3 | 15:18 | -3 | 14 |
| 8 |
|
FK Mladá Boleslav | 9 | 3 | 3 | 3 | 14:12 | 2 | 12 |
| 9 |
|
Sigma Olomouc | 9 | 3 | 1 | 5 | 12:11 | 1 | 10 |
| 10 |
|
1. FC Slovácko | 9 | 2 | 4 | 3 | 10:14 | -4 | 10 |
| 11 |
|
FK Teplice | 9 | 2 | 4 | 3 | 12:21 | -9 | 10 |
| 12 |
|
FK Jablonec | 9 | 2 | 4 | 3 | 15:15 | 0 | 10 |
| 13 |
|
Baník Ostrava | 9 | 2 | 4 | 3 | 13:13 | 0 | 10 |
| 14 |
|
FC Trinity Zlín | 9 | 1 | 5 | 3 | 8:13 | -5 | 8 |
| 15 |
|
Dynamo České Budějovice | 9 | 2 | 2 | 5 | 8:18 | -10 | 8 |
| 16 |
|
FK Pardubice | 9 | 1 | 0 | 8 | 4:23 | -19 | 3 |
| Play-off | |
| Play-off | |
| Relégation |
