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| 27.11.2021 | 15:00 | Dynamo České Budějovice | - | 1. FC Slovácko | 3:2 (0:1) | |
| 15:00 | FK Pardubice | - | Sigma Olomouc | 1:5 (1:2) | ||
| 15:00 | FC Fastav Zlín | - | Baník Ostrava | 2:2 (1:1) | ||
| 18:00 | Viktoria Plzeň | - | Bohemians Praha 1905 | 6:0 (3:0) | ||
| 28.11.2021 | 15:00 | FC Hradec Králové | - | MFK Karviná | 1:0 (1:0) | |
| 15:00 | FK Jablonec | - | FK Mladá Boleslav | 0:1 (0:0) | ||
| 15:00 | Slavia Praha | - | FK Teplice | 3:0 (2:0) | ||
| 18:00 | AC Sparta Praha | - | Slovan Liberec | 2:1 (1:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slavia Praha | 16 | 13 | 2 | 1 | 45:11 | 34 | 41 |
| 2 |
|
Viktoria Plzeň | 16 | 12 | 2 | 2 | 31:12 | 19 | 38 |
| 3 |
|
AC Sparta Praha | 16 | 11 | 3 | 2 | 38:20 | 18 | 36 |
| 4 |
|
1. FC Slovácko | 16 | 11 | 2 | 3 | 33:17 | 16 | 35 |
| 5 |
|
Baník Ostrava | 16 | 8 | 5 | 3 | 31:21 | 10 | 29 |
| 6 |
|
FC Hradec Králové | 16 | 6 | 6 | 4 | 22:22 | 0 | 24 |
| 7 |
|
FK Mladá Boleslav | 16 | 7 | 2 | 7 | 26:23 | 3 | 23 |
| 8 |
|
Sigma Olomouc | 16 | 5 | 6 | 5 | 29:24 | 5 | 21 |
| 9 |
|
Dynamo České Budějovice | 16 | 6 | 3 | 7 | 23:25 | -2 | 21 |
| 10 |
|
Slovan Liberec | 16 | 6 | 2 | 8 | 16:23 | -7 | 20 |
| 11 |
|
Bohemians Praha 1905 | 16 | 5 | 3 | 8 | 24:35 | -11 | 18 |
| 12 |
|
FC Fastav Zlín | 16 | 4 | 3 | 9 | 19:31 | -12 | 15 |
| 13 |
|
FK Jablonec | 16 | 2 | 7 | 7 | 11:29 | -18 | 13 |
| 14 |
|
FK Pardubice | 16 | 2 | 5 | 9 | 19:35 | -16 | 11 |
| 15 |
|
MFK Karviná | 16 | 0 | 5 | 11 | 14:31 | -17 | 5 |
| 16 |
|
FK Teplice | 16 | 1 | 2 | 13 | 13:35 | -22 | 5 |
| Play-off | |
| Play-off | |
| Relégation |
