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| H (Match allé) | Real Hope | - | Cruz Azul | 0:2 (0:1) | ||
| R (match retour) | Cruz Azul | - | Real Hope | 5:0 (3:0) | ||
| H (Match allé): 05.02.2025 02:00 | R (match retour): 12.02.2025 04:00 | vainqueur: Cruz Azul | ||||
| H (Match allé) | Forge FC | - | CF Monterrey | 0:2 (0:0) | ||
| R (match retour) | CF Monterrey | - | Forge FC | 3:0 (1:0) | ||
| H (Match allé): 06.02.2025 02:00 | R (match retour): 12.02.2025 02:00 | vainqueur: CF Monterrey | ||||
| H (Match allé) | Real Estelí FC | - | UANL Tigres | 1:0 (0:0) | ||
| R (match retour) | UANL Tigres | - | Real Estelí FC | 3:0 (2:0) | ||
| H (Match allé): 06.02.2025 04:00 | R (match retour): 13.02.2025 04:00 | vainqueur: UANL Tigres | ||||
| H (Match allé) | Cibao FC | - | Deportivo Guadalajara | 1:1 (1:0) | ||
| R (match retour) | Deportivo Guadalajara | - | Cibao FC | 3:0 (1:0) | ||
| H (Match allé): 07.02.2025 02:00 | R (match retour): 13.02.2025 02:00 | vainqueur: Deportivo Guadalajara | ||||
| H (Match allé) | Cavalry FC | - | Pumas UNAM | 2:1 (0:1) | ||
| R (match retour) | Pumas UNAM | - | Cavalry FC | 2:0 (0:0) | ||
| H (Match allé): 07.02.2025 04:00 | R (match retour): 14.02.2025 02:00 | vainqueur: Pumas UNAM | ||||
| H (Match allé) | Colorado Rapids | - | Los Angeles FC | 2:1 (0:0) | ||
| R (match retour) | Los Angeles FC | - | Colorado Rapids | 1:0 (0:0) | ||
| H (Match allé): 19.02.2025 04:00 | R (match retour): 26.02.2025 04:00 | vainqueur: Los Angeles FC | ||||
| H (Match allé) | CS Herediano | - | Real Salt Lake | 0:0 (0:0) | ||
| R (match retour) | Real Salt Lake | - | CS Herediano | 1:2 (1:0) | ||
| H (Match allé): 20.02.2025 00:30 | R (match retour): 27.02.2025 02:30 | vainqueur: CS Herediano | ||||
| H (Match allé) | Sporting Kansas City | - | Inter Miami CF | 0:1 (0:0) | ||
| R (match retour) | Inter Miami CF | - | Sporting Kansas City | 3:1 (3:0) | ||
| H (Match allé): 20.02.2025 02:00 | R (match retour): 26.02.2025 02:00 | vainqueur: Inter Miami CF | ||||
| H (Match allé) | Antigua GFC | - | Seattle Sounders | 1:3 (1:1) | ||
| R (match retour) | Seattle Sounders | - | Antigua GFC | 3:1 (1:1) | ||
| H (Match allé): 20.02.2025 02:00 | R (match retour): 27.02.2025 04:30 | vainqueur: Seattle Sounders | ||||
| H (Match allé) | Motagua | - | FC Cincinnati | 1:4 (1:1) | ||
| R (match retour) | FC Cincinnati | - | Motagua | 1:1 (1:1) | ||
| H (Match allé): 20.02.2025 04:00 | R (match retour): 27.02.2025 00:30 | vainqueur: FC Cincinnati | ||||
| H (Match allé) | Deportivo Saprissa | - | Vancouver Whitecaps | 2:1 (0:1) | ||
| R (match retour) | Vancouver Whitecaps | - | Deportivo Saprissa | 2:0 (0:0) | ||
| H (Match allé): 21.02.2025 02:00 | R (match retour): 28.02.2025 04:00 | vainqueur: Vancouver Whitecaps | ||||
