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| H (Match allé) | Santiago Morning | - | Deportes Temuco | 1:1 (0:0) | ||
| R (match retour) | Deportes Temuco | - | Santiago Morning | 2:1 (1:0) | ||
| H (Match allé): 25.11.2021 22:00 | R (match retour): 02.12.2021 00:30 | vainqueur: Deportes Temuco | ||||
| H (Match allé) | Puerto Montt | - | Deportes Copiapó | 0:1 (0:0) | ||
| R (match retour) | Deportes Copiapó | - | Puerto Montt | 2:2 (2:0) | ||
| H (Match allé): 26.11.2021 00:30 | R (match retour): 01.12.2021 21:45 | vainqueur: Deportes Copiapó | ||||
