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| 15.10.2021 | 20:30 | 1899 Hoffenheim | - | 1. FC Köln | 5:0 (1:0) | |
| 16.10.2021 | 15:30 | Borussia Dortmund | - | 1. FSV Mainz 05 | 3:1 (1:0) | |
| 15:30 | Eintracht Frankfurt | - | Hertha BSC | 1:2 (0:1) | ||
| 15:30 | 1. FC Union Berlin | - | VfL Wolfsburg | 2:0 (0:0) | ||
| 15:30 | SC Freiburg | - | RB Leipzig | 1:1 (0:1) | ||
| 15:30 | SpVgg Greuther Fürth | - | VfL Bochum | 0:1 (0:0) | ||
| 18:30 | Bor. Mönchengladbach | - | VfB Stuttgart | 1:1 (1:1) | ||
| 17.10.2021 | 15:30 | Bayer Leverkusen | - | Bayern München | 1:5 (0:5) | |
| 17:30 | FC Augsburg | - | Arminia Bielefeld | 1:1 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 8 | 6 | 1 | 1 | 29:8 | 21 | 19 |
| 2 |
|
Borussia Dortmund | 8 | 6 | 0 | 2 | 22:14 | 8 | 18 |
| 3 |
|
Bayer Leverkusen | 8 | 5 | 1 | 2 | 21:12 | 9 | 16 |
| 4 |
|
SC Freiburg | 8 | 4 | 4 | 0 | 12:6 | 6 | 16 |
| 5 |
|
1. FC Union Berlin | 8 | 4 | 3 | 1 | 12:9 | 3 | 15 |
| 6 |
|
VfL Wolfsburg | 8 | 4 | 1 | 3 | 9:10 | -1 | 13 |
| 7 |
|
1. FC Köln | 8 | 3 | 3 | 2 | 13:14 | -1 | 12 |
| 8 |
|
RB Leipzig | 8 | 3 | 2 | 3 | 16:8 | 8 | 11 |
| 9 |
|
1899 Hoffenheim | 8 | 3 | 2 | 3 | 17:11 | 6 | 11 |
| 10 |
|
Bor. Mönchengladbach | 8 | 3 | 2 | 3 | 10:11 | -1 | 11 |
| 11 |
|
1. FSV Mainz 05 | 8 | 3 | 1 | 4 | 8:8 | 0 | 10 |
| 12 |
|
VfB Stuttgart | 8 | 2 | 3 | 3 | 13:14 | -1 | 9 |
| 13 |
|
Hertha BSC | 8 | 3 | 0 | 5 | 10:21 | -11 | 9 |
| 14 |
|
Eintracht Frankfurt | 8 | 1 | 5 | 2 | 9:12 | -3 | 8 |
| 15 |
|
VfL Bochum | 8 | 2 | 1 | 5 | 5:16 | -11 | 7 |
| 16 |
|
FC Augsburg | 8 | 1 | 3 | 4 | 4:14 | -10 | 6 |
| 17 |
|
Arminia Bielefeld | 8 | 0 | 5 | 3 | 4:11 | -7 | 5 |
| 18 |
|
SpVgg Greuther Fürth | 8 | 0 | 1 | 7 | 5:20 | -15 | 1 |
| Champions League | |
| Europa League | |
| Relégation | |
| Relégation |
