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| 01.10.2021 | 20:30 | 1. FC Köln | - | SpVgg Greuther Fürth | 3:1 (0:1) | |
| 02.10.2021 | 15:30 | Borussia Dortmund | - | FC Augsburg | 2:1 (1:1) | |
| 15:30 | VfL Wolfsburg | - | Bor. Mönchengladbach | 1:3 (1:2) | ||
| 15:30 | VfB Stuttgart | - | 1899 Hoffenheim | 3:1 (1:0) | ||
| 15:30 | Hertha BSC | - | SC Freiburg | 1:2 (0:1) | ||
| 18:30 | RB Leipzig | - | VfL Bochum | 3:0 (0:0) | ||
| 03.10.2021 | 15:30 | 1. FSV Mainz 05 | - | 1. FC Union Berlin | 1:2 (1:0) | |
| 17:30 | Bayern München | - | Eintracht Frankfurt | 1:2 (1:1) | ||
| 19:30 | Arminia Bielefeld | - | Bayer Leverkusen | 0:4 (0:2) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bayern München | 7 | 5 | 1 | 1 | 24:7 | 17 | 16 |
| 2 |
|
Bayer Leverkusen | 7 | 5 | 1 | 1 | 20:7 | 13 | 16 |
| 3 |
|
Borussia Dortmund | 7 | 5 | 0 | 2 | 19:13 | 6 | 15 |
| 4 |
|
SC Freiburg | 7 | 4 | 3 | 0 | 11:5 | 6 | 15 |
| 5 |
|
VfL Wolfsburg | 7 | 4 | 1 | 2 | 9:8 | 1 | 13 |
| 6 |
|
1. FC Köln | 7 | 3 | 3 | 1 | 13:9 | 4 | 12 |
| 7 |
|
1. FC Union Berlin | 7 | 3 | 3 | 1 | 10:9 | 1 | 12 |
| 8 |
|
RB Leipzig | 7 | 3 | 1 | 3 | 15:7 | 8 | 10 |
| 9 |
|
1. FSV Mainz 05 | 7 | 3 | 1 | 3 | 7:5 | 2 | 10 |
| 10 |
|
Bor. Mönchengladbach | 7 | 3 | 1 | 3 | 9:10 | -1 | 10 |
| 11 |
|
1899 Hoffenheim | 7 | 2 | 2 | 3 | 12:11 | 1 | 8 |
| 12 |
|
VfB Stuttgart | 7 | 2 | 2 | 3 | 12:13 | -1 | 8 |
| 13 |
|
Eintracht Frankfurt | 7 | 1 | 5 | 1 | 8:10 | -2 | 8 |
| 14 |
|
Hertha BSC | 7 | 2 | 0 | 5 | 8:20 | -12 | 6 |
| 15 |
|
FC Augsburg | 7 | 1 | 2 | 4 | 3:13 | -10 | 5 |
| 16 |
|
Arminia Bielefeld | 7 | 0 | 4 | 3 | 3:10 | -7 | 4 |
| 17 |
|
VfL Bochum | 7 | 1 | 1 | 5 | 4:16 | -12 | 4 |
| 18 |
|
SpVgg Greuther Fürth | 7 | 0 | 1 | 6 | 5:19 | -14 | 1 |
| Champions League | |
| Europa League | |
| Relégation | |
| Relégation |
