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| 12.02.2022 | 01:00 | Oriente Petrolero | - | Club Aurora | 2:0 (0:0) | |
| 20:00 | Always Ready | - | Royal Pari | 2:2 (1:2) | ||
| 20:00 | Jorge Wilstermann | - | Blooming | 0:1 (0:1) | ||
| 13.02.2022 | 00:30 | Universitario de Sucre | - | Nacional Potosí | 4:3 (0:1) | |
| 17:00 | Atlético Palmaflor | - | The Strongest | 0:3 (0:1) | ||
| 20:00 | Real Santa Cruz | - | CD Guabirá | 2:2 (2:0) | ||
| 20:00 | Bolívar | - | Universitario de Vinto | 2:0 (1:0) | ||
| 22:15 | Real Tomayapo | - | Independiente Petrolero | 1:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
The Strongest | 2 | 2 | 0 | 0 | 5:0 | 5 | 6 |
| 2 |
|
Universitario de Sucre | 2 | 2 | 0 | 0 | 5:3 | 2 | 6 |
| 3 |
|
Oriente Petrolero | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 |
| 4 |
|
CD Guabirá | 2 | 0 | 2 | 0 | 2:2 | 0 | 2 |
| 5 |
|
Nacional Potosí | 2 | 0 | 1 | 1 | 4:5 | -1 | 1 |
| 6 |
|
Real Santa Cruz | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 |
| 7 |
|
Club Aurora | 2 | 0 | 1 | 1 | 0:2 | -2 | 1 |
| 8 |
|
Atlético Palmaflor | 2 | 0 | 1 | 1 | 1:4 | -3 | 1 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bolívar | 2 | 2 | 0 | 0 | 9:0 | 9 | 6 |
| 2 |
|
Always Ready | 2 | 1 | 1 | 0 | 4:3 | 1 | 4 |
| 3 |
|
Jorge Wilstermann | 2 | 1 | 0 | 1 | 2:1 | 1 | 3 |
| 4 |
|
Blooming | 2 | 1 | 0 | 1 | 1:7 | -6 | 3 |
| 5 |
|
Real Tomayapo | 2 | 0 | 2 | 0 | 2:2 | 0 | 2 |
| 6 |
|
Independiente Petrolero | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 |
| 7 |
|
Royal Pari | 2 | 0 | 1 | 1 | 2:4 | -2 | 1 |
| 8 |
|
Universitario de Vinto | 2 | 0 | 1 | 1 | 1:3 | -2 | 1 |
| Play-off | |
| Play-off |
