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| 29.04.2022 | 21:00 | CD Guabirá | - | Nacional Potosí | 1:2 (0:1) | |
| 30.04.2022 | 21:00 | The Strongest | - | Real Santa Cruz | 1:1 (0:0) | |
| 23:15 | Club Aurora | - | Universitario de Sucre | 3:0 (0:0) | ||
| 01.05.2022 | 01:30 | Royal Pari | - | Real Tomayapo | 6:1 (3:0) | |
| 01:30 | Independiente Petrolero | - | Jorge Wilstermann | 3:2 (2:0) | ||
| 21:00 | Always Ready | - | Bolívar | 1:2 (0:0) | ||
| 21:00 | Universitario de Vinto | - | Blooming | 2:1 (0:0) | ||
| 02.05.2022 | 02:00 | Oriente Petrolero | - | Atlético Palmaflor | 2:1 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| 1 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
The Strongest | 12 | 6 | 4 | 2 | 19:9 | 10 | 22 |
| 2 |
|
Atlético Palmaflor | 12 | 6 | 1 | 5 | 12:16 | -4 | 19 |
| 3 |
|
Nacional Potosí | 12 | 5 | 3 | 4 | 23:18 | 5 | 18 |
| 4 |
|
Oriente Petrolero | 12 | 5 | 3 | 4 | 16:14 | 2 | 18 |
| 5 |
|
Club Aurora | 12 | 4 | 4 | 4 | 14:13 | 1 | 16 |
| 6 |
|
Universitario de Sucre | 12 | 4 | 3 | 5 | 15:16 | -1 | 15 |
| 7 |
|
Real Santa Cruz | 12 | 3 | 3 | 6 | 15:18 | -3 | 12 |
| 8 |
|
CD Guabirá | 12 | 2 | 3 | 7 | 10:20 | -10 | 9 |
| 2 | |||||||||
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bolívar | 12 | 9 | 1 | 2 | 35:6 | 29 | 28 |
| 2 |
|
Blooming | 12 | 6 | 3 | 3 | 20:24 | -4 | 21 |
| 3 |
|
Royal Pari | 12 | 5 | 4 | 3 | 27:19 | 8 | 19 |
| 4 |
|
Real Tomayapo | 12 | 3 | 5 | 4 | 11:20 | -9 | 14 |
| 5 |
|
Jorge Wilstermann | 12 | 3 | 4 | 5 | 13:15 | -2 | 13 |
| 6 |
|
Always Ready | 12 | 3 | 4 | 5 | 15:19 | -4 | 13 |
| 7 |
|
Independiente Petrolero | 12 | 3 | 4 | 5 | 16:22 | -6 | 13 |
| 8 |
|
Universitario de Vinto | 12 | 3 | 3 | 6 | 13:25 | -12 | 12 |
| Play-off | |
| Play-off |
