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| H (Match allé) | Jorge Wilstermann | - | Blooming | 3:0 (2:0) | ||
| R (match retour) | Blooming | - | Jorge Wilstermann | 1:3 (1:3) | ||
| H (Match allé): 06.05.2018 21:00 | R (match retour): 14.05.2018 01:30 | vainqueur: Jorge Wilstermann | ||||
| H (Match allé) | Oriente Petrolero | - | The Strongest | 0:1 (0:0) | ||
| R (match retour) | The Strongest | - | Oriente Petrolero | 5:1 (4:0) | ||
| H (Match allé): 06.05.2018 21:00 | R (match retour): 12.05.2018 21:00 | vainqueur: The Strongest | ||||
| H (Match allé) | Nacional Potosí | - | Bolívar | 1:2 (1:1) | ||
| R (match retour) | Bolívar | - | Nacional Potosí | 1:0 (0:0) | ||
| H (Match allé): 06.05.2018 23:15 | R (match retour): 13.05.2018 02:45 | vainqueur: Bolívar | ||||
| H (Match allé) | Destroyers | - | Club San José | 1:0 (1:0) | ||
| R (match retour) | Club San José | - | Destroyers | 4:2 (4:0, 8:0) tab | ||
| H (Match allé): 07.05.2018 01:30 | R (match retour): 12.05.2018 23:15 | vainqueur: Club San José | ||||
