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| H (Match allé) | Bolívar | - | The Strongest | 0:1 (0:0) | ||
| R (match retour) | The Strongest | - | Bolívar | 1:1 (0:0) | ||
| H (Match allé): 20.05.2018 22:00 | R (match retour): 27.05.2018 23:15 | vainqueur: The Strongest | ||||
| H (Match allé) | Club San José | - | Jorge Wilstermann | 2:4 (1:3) | ||
| R (match retour) | Jorge Wilstermann | - | Club San José | 1:0 (0:0) | ||
| H (Match allé): 20.05.2018 23:15 | R (match retour): 27.05.2018 21:00 | vainqueur: Jorge Wilstermann | ||||
