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| 04.10.2021 | 19:30 | KAS Eupen II | - | RFC Seraing II | 2:1 | |
| 19:30 | KV Oostende II | - | Royal Excel Mouscron II | 1:0 | ||
| 20:00 | Excelsior Virton II | - | Lierse SK II | 2:2 | ||
| 20:00 | Union St. Gilloise II | - | KV Kortrijk II | 1:0 | ||
| 20:00 | SK Beveren II | - | SK Deinze II | 1:1 | ||
| 20:00 | Lommel SK II | - | KVC Westerlo II | 1:2 | ||
| 20:30 | RWD Molenbeek II | - | K Beerschot VA II | 1:5 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 6 | 4 | 1 | 1 | 14:7 | 7 | 13 |
| 2 |
|
Lierse SK II | 6 | 4 | 1 | 1 | 9:11 | -2 | 13 |
| 3 |
|
KV Oostende II | 6 | 3 | 3 | 0 | 17:7 | 10 | 12 |
| 4 |
|
SK Beveren II | 6 | 3 | 1 | 2 | 11:4 | 7 | 10 |
| 5 |
|
Union St. Gilloise II | 6 | 3 | 1 | 2 | 6:6 | 0 | 10 |
| 6 |
|
Royal Excel Mouscron II | 6 | 3 | 0 | 3 | 6:3 | 3 | 9 |
| 7 |
|
KVC Westerlo II | 6 | 3 | 0 | 3 | 8:8 | 0 | 9 |
| 8 |
|
RFC Seraing II | 6 | 3 | 0 | 3 | 6:6 | 0 | 9 |
| 9 |
|
K Beerschot VA II | 6 | 2 | 2 | 2 | 8:6 | 2 | 8 |
| 10 |
|
Excelsior Virton II | 6 | 2 | 2 | 2 | 11:17 | -6 | 8 |
| 11 |
|
RWD Molenbeek II | 6 | 2 | 1 | 3 | 12:15 | -3 | 7 |
| 12 |
|
SK Deinze II | 6 | 2 | 1 | 3 | 4:7 | -3 | 7 |
| 13 |
|
Lommel SK II | 6 | 1 | 1 | 4 | 9:12 | -3 | 4 |
| 14 |
|
KV Kortrijk II | 6 | 0 | 0 | 6 | 1:13 | -12 | 0 |
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