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| 14.03.2022 | 19:30 | SK Beveren II | - | KV Oostende II | 0:2 | |
| 20:00 | SK Deinze II | - | KAS Eupen II | 2:3 | ||
| 20:00 | Union St. Gilloise II | - | Royal Excel Mouscron II | 1:2 | ||
| 20:00 | K Beerschot VA II | - | KVC Westerlo II | 1:0 | ||
| 20:00 | Lommel SK II | - | KV Kortrijk II | 1:4 | ||
| 20:30 | RWD Molenbeek II | - | Lierse SK II | 1:0 (0:0) | ||
| 14.04.2022 | 16:00 | Excelsior Virton II | - | RFC Seraing II | 0:6 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
K Beerschot VA II | 22 | 16 | 4 | 2 | 55:18 | 37 | 52 |
| 2 |
|
KAS Eupen II | 22 | 16 | 2 | 4 | 53:26 | 27 | 50 |
| 3 |
|
KV Oostende II | 22 | 12 | 7 | 3 | 53:27 | 26 | 43 |
| 4 |
|
Royal Excel Mouscron II | 22 | 11 | 4 | 7 | 46:26 | 20 | 37 |
| 5 |
|
Excelsior Virton II | 22 | 11 | 2 | 9 | 50:58 | -8 | 35 |
| 6 |
|
SK Beveren II | 22 | 11 | 1 | 10 | 37:25 | 12 | 34 |
| 7 |
|
Union St. Gilloise II | 22 | 10 | 4 | 8 | 31:23 | 8 | 34 |
| 8 |
|
RWD Molenbeek II | 22 | 10 | 2 | 10 | 45:45 | 0 | 32 |
| 9 |
|
RFC Seraing II | 22 | 9 | 2 | 11 | 35:36 | -1 | 29 |
| 10 |
|
KVC Westerlo II | 22 | 8 | 2 | 12 | 34:40 | -6 | 26 |
| 11 |
|
Lierse SK II | 22 | 6 | 4 | 12 | 25:53 | -28 | 22 |
| 12 |
|
SK Deinze II | 22 | 5 | 3 | 14 | 23:49 | -26 | 18 |
| 13 |
|
Lommel SK II | 22 | 4 | 3 | 15 | 20:54 | -34 | 15 |
| 14 |
|
KV Kortrijk II | 22 | 2 | 6 | 14 | 27:54 | -27 | 12 |
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