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| 06.12.2021 | 19:30 | Royal Excel Mouscron II | - | KVC Westerlo II | 3:2 | |
| 19:30 | KAS Eupen II | - | K Beerschot VA II | 0:3 | ||
| 20:00 | SK Deinze II | - | RWD Molenbeek II | 3:3 | ||
| 20:00 | Lierse SK II | - | KV Kortrijk II | 4:1 | ||
| 20:00 | RFC Seraing II | - | Lommel SK II | 6:0 | ||
| 12.01.2022 | 19:00 | KV Oostende II | - | SK Beveren II | 3:1 | |
| 07.04.2022 | 16:00 | Excelsior Virton II | - | Union St. Gilloise II | 1:2 |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 13 | 9 | 1 | 3 | 29:16 | 13 | 28 |
| 2 |
|
K Beerschot VA II | 13 | 8 | 3 | 2 | 29:13 | 16 | 27 |
| 3 |
|
KV Oostende II | 13 | 7 | 5 | 1 | 32:14 | 18 | 26 |
| 4 |
|
RWD Molenbeek II | 13 | 7 | 2 | 4 | 35:25 | 10 | 23 |
| 5 |
|
Royal Excel Mouscron II | 13 | 6 | 2 | 5 | 22:14 | 8 | 20 |
| 6 |
|
Union St. Gilloise II | 13 | 6 | 2 | 5 | 16:11 | 5 | 20 |
| 7 |
|
Excelsior Virton II | 13 | 6 | 2 | 5 | 28:35 | -7 | 20 |
| 8 |
|
SK Beveren II | 13 | 6 | 1 | 6 | 21:14 | 7 | 19 |
| 9 |
|
Lierse SK II | 13 | 5 | 4 | 4 | 19:25 | -6 | 19 |
| 10 |
|
KVC Westerlo II | 13 | 5 | 2 | 6 | 19:21 | -2 | 17 |
| 11 |
|
SK Deinze II | 13 | 4 | 2 | 7 | 14:25 | -11 | 14 |
| 12 |
|
RFC Seraing II | 13 | 4 | 0 | 9 | 17:29 | -12 | 12 |
| 13 |
|
KV Kortrijk II | 13 | 1 | 3 | 9 | 13:31 | -18 | 6 |
| 14 |
|
Lommel SK II | 13 | 1 | 3 | 9 | 10:31 | -21 | 6 |
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