 |
 |
|
|
| 17.12.2021 | 20:45 | RFC Seraing | - | KV Kortrijk | 0:2 (0:0) | |
| 18.12.2021 | 16:15 | K Beerschot VA | - | KV Oostende | 0:2 (0:2) | |
| 18:30 | Union Saint-Gilloise | - | Cercle Brugge | 3:2 (0:2) | ||
| 18:30 | SV Zulte Waregem | - | KV Mechelen | 3:2 (0:1) | ||
| 20:45 | KAA Gent | - | Sint-Truidense VV | 2:1 (1:0) | ||
| 19.12.2021 | 13:30 | Club Brugge KV | - | RSC Anderlecht | 2:2 (1:0) | |
| 16:00 | KAS Eupen | - | Sporting Charleroi | 0:4 (0:3) | ||
| 18:30 | KRC Genk | - | Royal Antwerp FC | 1:1 (1:0) | ||
| 21:00 | Oud-Heverlee Leuven | - | Standard Liège | 2:1 (2:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Union Saint-Gilloise | 20 | 15 | 1 | 4 | 50:20 | 30 | 46 |
| 2 |
|
Club Brugge KV | 20 | 11 | 7 | 2 | 41:26 | 15 | 40 |
| 3 |
|
Royal Antwerp FC | 20 | 11 | 4 | 5 | 37:24 | 13 | 37 |
| 4 |
|
RSC Anderlecht | 20 | 9 | 8 | 3 | 43:26 | 17 | 35 |
| 5 |
|
Sporting Charleroi | 20 | 10 | 5 | 5 | 38:26 | 12 | 35 |
| 6 |
|
KAA Gent | 20 | 10 | 3 | 7 | 33:22 | 11 | 33 |
| 7 |
|
KV Kortrijk | 20 | 8 | 7 | 5 | 26:22 | 4 | 31 |
| 8 |
|
KV Mechelen | 20 | 9 | 3 | 8 | 35:37 | -2 | 30 |
| 9 |
|
KRC Genk | 20 | 7 | 5 | 8 | 36:33 | 3 | 26 |
| 10 |
|
Standard Liège | 20 | 7 | 5 | 8 | 23:33 | -10 | 26 |
| 11 |
|
KAS Eupen | 20 | 7 | 4 | 9 | 30:34 | -4 | 25 |
| 12 |
|
Oud-Heverlee Leuven | 20 | 5 | 8 | 7 | 26:34 | -8 | 23 |
| 13 |
|
KV Oostende | 20 | 7 | 2 | 11 | 23:39 | -16 | 23 |
| 14 |
|
Cercle Brugge | 20 | 6 | 4 | 10 | 26:28 | -2 | 22 |
| 15 |
|
Sint-Truidense VV | 20 | 6 | 3 | 11 | 20:31 | -11 | 21 |
| 16 |
|
SV Zulte Waregem | 20 | 5 | 5 | 10 | 30:45 | -15 | 20 |
| 17 |
|
RFC Seraing | 20 | 6 | 1 | 13 | 23:40 | -17 | 19 |
| 18 |
|
K Beerschot VA | 20 | 2 | 3 | 15 | 15:35 | -20 | 9 |
| Play-off | |
| Play-off | |
| Relégation | |
| Relégation |
