 |
 |
|
|
| 10.12.2021 | 20:45 | Sporting Charleroi | - | KV Oostende | 1:0 (0:0) | |
| 11.12.2021 | 16:15 | KV Kortrijk | - | Oud-Heverlee Leuven | 2:1 (0:0) | |
| 18:30 | KAS Eupen | - | K Beerschot VA | 1:0 (1:0) | ||
| 18:30 | Sint-Truidense VV | - | Cercle Brugge | 1:2 (0:0) | ||
| 20:45 | RFC Seraing | - | RSC Anderlecht | 0:5 (0:3) | ||
| 12.12.2021 | 13:30 | Royal Antwerp FC | - | Standard Liège | 2:3 (0:0) | |
| 16:00 | Union Saint-Gilloise | - | KV Mechelen | 2:0 (1:0) | ||
| 18:30 | KAA Gent | - | KRC Genk | 1:0 (1:0) | ||
| 21:00 | Club Brugge KV | - | SV Zulte Waregem | 3:0 (1:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Union Saint-Gilloise | 18 | 13 | 1 | 4 | 45:18 | 27 | 40 |
| 2 |
|
Club Brugge KV | 18 | 10 | 6 | 2 | 35:23 | 12 | 36 |
| 3 |
|
Royal Antwerp FC | 18 | 10 | 3 | 5 | 32:21 | 11 | 33 |
| 4 |
|
Sporting Charleroi | 18 | 9 | 5 | 4 | 32:22 | 10 | 32 |
| 5 |
|
RSC Anderlecht | 18 | 8 | 7 | 3 | 39:24 | 15 | 31 |
| 6 |
|
KAA Gent | 18 | 9 | 3 | 6 | 28:17 | 11 | 30 |
| 7 |
|
KV Mechelen | 18 | 8 | 3 | 7 | 29:31 | -2 | 27 |
| 8 |
|
KAS Eupen | 18 | 7 | 4 | 7 | 28:26 | 2 | 25 |
| 9 |
|
KV Kortrijk | 18 | 6 | 7 | 5 | 22:22 | 0 | 25 |
| 10 |
|
Standard Liège | 18 | 6 | 5 | 7 | 21:31 | -10 | 23 |
| 11 |
|
KRC Genk | 18 | 6 | 4 | 8 | 31:30 | 1 | 22 |
| 12 |
|
Sint-Truidense VV | 18 | 6 | 3 | 9 | 19:27 | -8 | 21 |
| 13 |
|
Oud-Heverlee Leuven | 18 | 4 | 8 | 6 | 23:29 | -6 | 20 |
| 14 |
|
KV Oostende | 18 | 6 | 2 | 10 | 21:37 | -16 | 20 |
| 15 |
|
Cercle Brugge | 18 | 5 | 4 | 9 | 22:25 | -3 | 19 |
| 16 |
|
RFC Seraing | 18 | 6 | 1 | 11 | 23:36 | -13 | 19 |
| 17 |
|
SV Zulte Waregem | 18 | 4 | 5 | 9 | 27:41 | -14 | 17 |
| 18 |
|
K Beerschot VA | 18 | 2 | 3 | 13 | 15:32 | -17 | 9 |
| Play-off | |
| Play-off | |
| Relégation | |
| Relégation |
