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| 27.08.2022 | 20:00 | KVV THES Sport Tessenderlo | - | Hoogstraten VV | 3:1 (1:1) | |
| 28.08.2022 | 15:00 | Royal Francs Borains | - | Rupel Boom FC | 3:1 (1:0) | |
| 16:00 | R. Cappellen FC | - | KSK Heist | 2:1 (2:0) | ||
| 16:00 | Patro Eisden MM | - | KVK Westhoek | 3:0 (2:0) | ||
| 16:00 | KSC Lokeren-Temse | - | Tempo Overijse | 1:0 (1:0) | ||
| 16:00 | RFC Meux | - | Sporting Hasselt | 4:1 (0:1) | ||
| 06.09.2022 | 19:30 | St. Eloois-Winkel Sport | - | RFC Seraing | 0:2 (0:1) | |
| 21.09.2022 | 20:00 | Bocholter VV | - | SK Deinze | 1:2 (0:1, 1:1) ap | |
| 23.09.2022 | 20:00 | KFC Dessel Sport | - | Excelsior Virton | 2:1 (0:1, 1:1) ap | |
| 24.09.2022 | 19:30 | KSV Oudenaarde | - | RWD Molenbeek | 0:3 (0:1) | |
| 19:30 | FCV Dender EH | - | SC Dikkelvenne | 2:0 (0:0) | ||
| 20:00 | Lierse Kempenzonen | - | KRC Mechelen | 5:1 (1:0) | ||
| 20:00 | RAA La Louviére | - | Lommel SK | 0:2 (0:0) | ||
| 25.09.2022 | 16:00 | Eendracht Aalst | - | KVC Westerlo | 1:3 (1:0, 1:1) ap | |
| 16:00 | Royal Knokke FC | - | K Beerschot VA | 0:4 (0:1) | ||
| 16:00 | URSL Visé | - | SK Beveren | 0:2 (0:0) |
