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| 19.09.2017 | 20:00 | KV Kortrijk | - | RES Durbuysienne | 5:3 (3:2) | |
| 20:30 | Royal Antwerp FC | - | Lierse SK (old) | 2:0 (0:0) | ||
| 20:30 | Sint-Truidense VV | - | Oud-Heverlee Leuven | 4:2 (1:0, 1:1) ap | ||
| 20.09.2017 | 20:00 | KV Mechelen | - | Bocholter VV | 3:0 (2:0) | |
| 20:00 | RFC Liège | - | SV Zulte Waregem | 2:3 (1:1) | ||
| 20:00 | KV Oostende | - | Union Saint-Gilloise | 3:1 (1:0) | ||
| 20:00 | Lommel SK | - | Waasland-Beveren | 1:2 (1:2) | ||
| 20:00 | Cercle Brugge | - | KRC Genk | 0:1 (0:1) | ||
| 20:00 | Royal Excel Mouscron | - | AFC Tubize | 3:1 (2:0) | ||
| 20:30 | Sporting Lokeren | - | KFCO Beerschot Wilrijk | 2:0 (1:0) | ||
| 20:30 | KSV Roeselare | - | Club Brugge KV | 1:5 (1:4) | ||
| 20:30 | ASV Geel | - | KAA Gent | 2:3 (0:1) | ||
| 20:30 | KAS Eupen | - | Rupel Boom FC | 3:2 (2:2) | ||
| 20:45 | KVC Westerlo | - | RSC Anderlecht | 0:1 (0:0) | ||
| 20:45 | Standard Liège | - | KSK Heist | 4:0 (2:0) | ||
| 21.09.2017 | 20:45 | Sporting Charleroi | - | UR La Louvière Centre | 4:0 (2:0) |
