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| 22.08.2015 | 18:00 | Excelsior Virton | - | Bocholter VV | 0:1 ap | |
| 19:30 | SK Berlare | - | KAS Eupen | 1:3 | ||
| 19:30 | KFC Dessel Sport | - | KSV Bornem | 2:0 | ||
| 20:00 | SK Deinze | - | AFC Tubize | 3:1 | ||
| 20:00 | Cercle Brugge | - | RFC Liège | 2:0 | ||
| 23.08.2015 | 16:00 | Olsa Brakel | - | KSK Heist | 3:2 | |
| 16:00 | Royal Antwerp FC | - | RFC Seraing | 2:1 | ||
| 16:00 | KVV Coxyde | - | KFC Merelbeke | 1:0 | ||
| 16:00 | Royal Knokke FC | - | FCV Dender EH | 2:4 ap | ||
| 16:00 | KFC Duffel | - | Union Saint-Gilloise | 1:3 | ||
| 16:00 | White Star Bruxelles | - | Lierse SK (old) | 2:0 | ||
| 16:00 | Wallonia Walhain CG | - | RACS Couillet | 4:1 | ||
| 16:00 | Spouwen-Mopertingen | - | KFC Oosterzonen | 3:2 ap | ||
| 16:00 | RES Acrenoise | - | RRC Hamoir | 2:0 | ||
| 16:00 | SK Londerzeel | - | Lommel United | 0:1 ap | ||
| 16:00 | Patro Eisden MM | - | RC Hades | 5:0 |
