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| 09.04.2022 | 11:00 | SV Wehen Wiesbaden | - | FC Ingolstadt 04 | 2:1 (2:0) | |
| 12:00 | 1899 Hoffenheim | - | SC Freiburg | 1:1 (1:0) | ||
| 13:00 | FSV Frankfurt | - | 1. FC Nürnberg | 0:3 (0:2) | ||
| 13:00 | SpVgg Unterhaching | - | Bayern München | 3:1 (2:0) | ||
| 13:00 | 1. FSV Mainz 05 | - | Stuttgarter Kickers | 1:4 (0:1) | ||
| 13:00 | VfB Stuttgart | - | FC Augsburg | 1:1 (1:0) | ||
| 13:00 | TSV 1860 München | - | Eintracht Frankfurt | 2:3 (1:2) | ||
| 13:00 | 1. FC Heidenheim 1846 | - | SV Darmstadt 98 | 1:3 (1:0) | ||
| 16.04.2022 | 13:00 | Karlsruher SC | - | SSV Reutlingen | 0:0 (0:0) | |
| 21.04.2022 | 14:00 | SV 07 Elversberg | - | SpVgg Greuther Fürth | 2:2 (2:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 19 | 16 | 3 | 0 | 61:16 | 45 | 51 |
| 2 |
|
SpVgg Unterhaching | 19 | 15 | 0 | 4 | 45:28 | 17 | 45 |
| 3 |
|
1899 Hoffenheim | 19 | 12 | 3 | 4 | 46:27 | 19 | 39 |
| 4 |
|
SC Freiburg | 19 | 12 | 2 | 5 | 54:30 | 24 | 38 |
| 5 |
|
1. FSV Mainz 05 | 19 | 10 | 5 | 4 | 49:26 | 23 | 35 |
| 6 |
|
Bayern München | 19 | 11 | 2 | 6 | 50:30 | 20 | 35 |
| 7 |
|
1. FC Nürnberg | 20 | 10 | 3 | 7 | 51:29 | 22 | 33 |
| 8 |
|
FC Augsburg | 19 | 10 | 3 | 6 | 41:30 | 11 | 33 |
| 9 |
|
SV Darmstadt 98 | 19 | 11 | 0 | 8 | 36:36 | 0 | 33 |
| 10 |
|
SpVgg Greuther Fürth | 19 | 9 | 4 | 6 | 29:23 | 6 | 31 |
| 11 |
|
Karlsruher SC | 19 | 7 | 5 | 7 | 29:25 | 4 | 26 |
| 12 |
|
Eintracht Frankfurt | 19 | 7 | 4 | 8 | 27:30 | -3 | 25 |
| 13 |
|
Stuttgarter Kickers | 19 | 8 | 1 | 10 | 29:34 | -5 | 25 |
| 14 |
|
TSV 1860 München | 19 | 7 | 2 | 10 | 22:28 | -6 | 23 |
| 15 |
|
1. FC Kaiserslautern | 19 | 6 | 2 | 11 | 41:44 | -3 | 20 |
| 16 |
|
FSV Frankfurt | 19 | 6 | 2 | 11 | 23:32 | -9 | 20 |
| 17 |
|
1. FC Heidenheim 1846 | 19 | 5 | 4 | 10 | 31:49 | -18 | 19 |
| 18 |
|
SV Wehen Wiesbaden | 19 | 5 | 1 | 13 | 21:49 | -28 | 16 |
| 19 |
|
FC Ingolstadt 04 | 19 | 3 | 5 | 11 | 18:49 | -31 | 14 |
| 20 |
|
SV 07 Elversberg | 19 | 2 | 2 | 15 | 11:57 | -46 | 8 |
| 21 |
|
SSV Reutlingen | 19 | 0 | 3 | 16 | 13:55 | -42 | 3 |
| Play-off | |
| Relégation |
