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| 02.04.2022 | 11:00 | FC Ingolstadt 04 | - | Karlsruher SC | 0:2 (0:2) | |
| 11:00 | FC Augsburg | - | SV 07 Elversberg | 4:1 (3:0) | ||
| 11:00 | Bayern München | - | 1. FSV Mainz 05 | 2:1 (1:0) | ||
| 12:30 | SpVgg Greuther Fürth | - | SV Wehen Wiesbaden | 4:0 (2:0) | ||
| 03.04.2022 | 11:00 | Eintracht Frankfurt | - | 1. FC Heidenheim 1846 | 2:0 (0:0) | |
| 11:00 | SC Freiburg | - | TSV 1860 München | 2:1 (2:0) | ||
| 13:00 | SV Darmstadt 98 | - | 1. FC Kaiserslautern | 3:1 (0:0) | ||
| 06.04.2022 | 18:30 | 1. FC Nürnberg | - | SpVgg Unterhaching | 2:0 (1:0) | |
| 16.04.2022 | 11:00 | Stuttgarter Kickers | - | VfB Stuttgart | 0:1 (0:0) | |
| 20.04.2022 | 17:00 | SSV Reutlingen | - | 1899 Hoffenheim | 1:3 (1:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 18 | 16 | 2 | 0 | 60:15 | 45 | 50 |
| 2 |
|
SpVgg Unterhaching | 18 | 14 | 0 | 4 | 42:27 | 15 | 42 |
| 3 |
|
1899 Hoffenheim | 18 | 12 | 2 | 4 | 45:26 | 19 | 38 |
| 4 |
|
SC Freiburg | 18 | 12 | 1 | 5 | 53:29 | 24 | 37 |
| 5 |
|
1. FSV Mainz 05 | 18 | 10 | 5 | 3 | 48:22 | 26 | 35 |
| 6 |
|
Bayern München | 18 | 11 | 2 | 5 | 49:27 | 22 | 35 |
| 7 |
|
FC Augsburg | 18 | 10 | 2 | 6 | 40:29 | 11 | 32 |
| 8 |
|
1. FC Nürnberg | 19 | 9 | 3 | 7 | 48:29 | 19 | 30 |
| 9 |
|
SpVgg Greuther Fürth | 18 | 9 | 3 | 6 | 27:21 | 6 | 30 |
| 10 |
|
SV Darmstadt 98 | 18 | 10 | 0 | 8 | 33:35 | -2 | 30 |
| 11 |
|
Karlsruher SC | 18 | 7 | 4 | 7 | 29:25 | 4 | 25 |
| 12 |
|
TSV 1860 München | 18 | 7 | 2 | 9 | 20:25 | -5 | 23 |
| 13 |
|
Eintracht Frankfurt | 18 | 6 | 4 | 8 | 24:28 | -4 | 22 |
| 14 |
|
Stuttgarter Kickers | 18 | 7 | 1 | 10 | 25:33 | -8 | 22 |
| 15 |
|
1. FC Kaiserslautern | 19 | 6 | 2 | 11 | 41:44 | -3 | 20 |
| 16 |
|
FSV Frankfurt | 18 | 6 | 2 | 10 | 23:29 | -6 | 20 |
| 17 |
|
1. FC Heidenheim 1846 | 18 | 5 | 4 | 9 | 30:46 | -16 | 19 |
| 18 |
|
FC Ingolstadt 04 | 18 | 3 | 5 | 10 | 17:47 | -30 | 14 |
| 19 |
|
SV Wehen Wiesbaden | 18 | 4 | 1 | 13 | 19:48 | -29 | 13 |
| 20 |
|
SV 07 Elversberg | 18 | 2 | 1 | 15 | 9:55 | -46 | 7 |
| 21 |
|
SSV Reutlingen | 18 | 0 | 2 | 16 | 13:55 | -42 | 2 |
| Play-off | |
| Relégation |
