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| 11.12.2021 | 11:00 | SV Darmstadt 98 | - | FC Ingolstadt 04 | 7:2 (5:1) | |
| 11:00 | SV Wehen Wiesbaden | - | FSV Frankfurt | 2:1 (2:1) | ||
| 11:00 | 1899 Hoffenheim | - | Bayern München | 0:2 (0:1) | ||
| 13:00 | 1. FC Heidenheim 1846 | - | FC Augsburg | 1:1 (1:1) | ||
| 14:00 | 1. FC Kaiserslautern | - | SpVgg Greuther Fürth | 1:2 (0:2) | ||
| 14:00 | Eintracht Frankfurt | - | SSV Reutlingen | 3:1 (1:1) | ||
| 14:00 | Karlsruher SC | - | 1. FC Nürnberg | 1:1 (1:0) | ||
| 12.12.2021 | 13:00 | TSV 1860 München | - | Stuttgarter Kickers | 1:0 (0:0) | |
| 13:30 | VfB Stuttgart | - | 1. FSV Mainz 05 | 1:1 (1:0) | ||
| 01.03.2022 | 18:30 | SV 07 Elversberg | - | SpVgg Unterhaching | 0:1 (0:1) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SpVgg Unterhaching | 14 | 12 | 0 | 2 | 36:17 | 19 | 36 |
| 2 |
|
VfB Stuttgart | 13 | 11 | 2 | 0 | 45:13 | 32 | 35 |
| 3 |
|
1. FSV Mainz 05 | 14 | 9 | 4 | 1 | 41:14 | 27 | 31 |
| 4 |
|
SC Freiburg | 13 | 9 | 1 | 3 | 39:18 | 21 | 28 |
| 5 |
|
1899 Hoffenheim | 13 | 9 | 0 | 4 | 36:21 | 15 | 27 |
| 6 |
|
Bayern München | 13 | 8 | 1 | 4 | 34:16 | 18 | 25 |
| 7 |
|
FC Augsburg | 13 | 8 | 1 | 4 | 29:20 | 9 | 25 |
| 8 |
|
SpVgg Greuther Fürth | 13 | 7 | 2 | 4 | 19:16 | 3 | 23 |
| 9 |
|
1. FC Nürnberg | 14 | 6 | 2 | 6 | 33:25 | 8 | 20 |
| 10 |
|
TSV 1860 München | 13 | 6 | 1 | 6 | 14:16 | -2 | 19 |
| 11 |
|
SV Darmstadt 98 | 14 | 6 | 0 | 8 | 25:33 | -8 | 18 |
| 12 |
|
FSV Frankfurt | 14 | 5 | 2 | 7 | 18:21 | -3 | 17 |
| 13 |
|
Eintracht Frankfurt | 14 | 4 | 4 | 6 | 20:25 | -5 | 16 |
| 14 |
|
Stuttgarter Kickers | 13 | 5 | 1 | 7 | 21:27 | -6 | 16 |
| 15 |
|
1. FC Heidenheim 1846 | 13 | 4 | 4 | 5 | 26:34 | -8 | 16 |
| 16 |
|
Karlsruher SC | 13 | 3 | 3 | 7 | 17:21 | -4 | 12 |
| 17 |
|
1. FC Kaiserslautern | 14 | 3 | 2 | 9 | 28:35 | -7 | 11 |
| 18 |
|
SV Wehen Wiesbaden | 13 | 3 | 1 | 9 | 15:35 | -20 | 10 |
| 19 |
|
SV 07 Elversberg | 13 | 2 | 1 | 10 | 8:35 | -27 | 7 |
| 20 |
|
FC Ingolstadt 04 | 13 | 1 | 4 | 8 | 13:41 | -28 | 7 |
| 21 |
|
SSV Reutlingen | 13 | 0 | 2 | 11 | 10:44 | -34 | 2 |
| Play-off | |
| Relégation |
