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| 06.11.2021 | 11:00 | 1. FC Kaiserslautern | - | 1. FC Nürnberg | 2:4 (2:1) | |
| 11:00 | SV Darmstadt 98 | - | Bayern München | 1:3 (1:0) | ||
| 11:00 | SC Freiburg | - | FC Augsburg | 4:3 (1:2) | ||
| 12:00 | Karlsruher SC | - | VfB Stuttgart | 0:3 (0:1) | ||
| 12:00 | 1899 Hoffenheim | - | 1. FSV Mainz 05 | 1:3 (1:1) | ||
| 13:00 | Eintracht Frankfurt | - | Stuttgarter Kickers | 2:2 (2:0) | ||
| 14:00 | 1. FC Heidenheim 1846 | - | FSV Frankfurt | 3:1 (1:1) | ||
| 07.11.2021 | 13:00 | SV Wehen Wiesbaden | - | SV 07 Elversberg | 0:0 (0:0) | |
| 14:00 | SSV Reutlingen | - | SpVgg Greuther Fürth | 2:3 (1:2) | ||
| 16.11.2021 | 15:00 | TSV 1860 München | - | SpVgg Unterhaching | 0:2 (0:0) |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 10 | 9 | 1 | 0 | 36:11 | 25 | 28 |
| 2 |
|
SpVgg Unterhaching | 10 | 9 | 0 | 1 | 30:12 | 18 | 27 |
| 3 |
|
Bayern München | 9 | 7 | 0 | 2 | 29:11 | 18 | 21 |
| 4 |
|
1. FSV Mainz 05 | 10 | 6 | 3 | 1 | 28:12 | 16 | 21 |
| 5 |
|
SC Freiburg | 10 | 7 | 0 | 3 | 28:18 | 10 | 21 |
| 6 |
|
1899 Hoffenheim | 9 | 6 | 0 | 3 | 28:17 | 11 | 18 |
| 7 |
|
FC Augsburg | 9 | 6 | 0 | 3 | 21:16 | 5 | 18 |
| 8 |
|
1. FC Nürnberg | 10 | 5 | 1 | 4 | 25:17 | 8 | 16 |
| 9 |
|
SpVgg Greuther Fürth | 9 | 4 | 1 | 4 | 12:13 | -1 | 13 |
| 10 |
|
Stuttgarter Kickers | 9 | 4 | 1 | 4 | 18:21 | -3 | 13 |
| 11 |
|
Eintracht Frankfurt | 10 | 3 | 3 | 4 | 14:17 | -3 | 12 |
| 12 |
|
Karlsruher SC | 9 | 3 | 2 | 4 | 14:12 | 2 | 11 |
| 13 |
|
FSV Frankfurt | 10 | 3 | 2 | 5 | 12:15 | -3 | 11 |
| 14 |
|
1. FC Heidenheim 1846 | 9 | 3 | 2 | 4 | 19:26 | -7 | 11 |
| 15 |
|
TSV 1860 München | 9 | 3 | 1 | 5 | 9:13 | -4 | 10 |
| 16 |
|
SV Darmstadt 98 | 10 | 3 | 0 | 7 | 14:29 | -15 | 9 |
| 17 |
|
1. FC Kaiserslautern | 10 | 2 | 2 | 6 | 23:25 | -2 | 8 |
| 18 |
|
SV Wehen Wiesbaden | 9 | 2 | 1 | 6 | 10:22 | -12 | 7 |
| 19 |
|
SV 07 Elversberg | 10 | 2 | 1 | 7 | 8:27 | -19 | 7 |
| 20 |
|
FC Ingolstadt 04 | 9 | 1 | 2 | 6 | 8:24 | -16 | 5 |
| 21 |
|
SSV Reutlingen | 10 | 0 | 1 | 9 | 7:35 | -28 | 1 |
| Play-off | |
| Relégation |
