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| 18.09.2022 | 16:00 | Juventud Unida de Gualeguaychú | - | Defensores de Pronunciamiento | 1:0 (1:0) | |
| 21:00 | Boca Unidos | - | Unión de Sunchales | 2:0 (1:0) | ||
| 21:00 | Crucero del Norte | - | Atlético Paraná | 1:0 (0:0) | ||
| 21:00 | Gimnasia y Esgrima (CdU) | - | San Martín de Formosa | 0:2 (0:0) | ||
| 21:30 | Racing de Córdoba | - | Central Norte | 1:0 (1:0) | ||
| 23:30 | Belgrano de San Francisco | - | Defensores Belgrano (VR) | 0:1 (0:1) | ||
| 20.09.2022 | 02:05 | Sarmiento de Resistencia | - | Douglas Haig | 2:1 (1:1) | |
| 22.09.2022 | 03:15 | Juventud Antoniana | - | Gimnasia y Tiro de Salta | 1:1 (0:0) |
| » Classement | équipe recevante | à l'extérieur | Premier tour | Second tour |
| # | Équipe | M. | G. | N. | P. | Buts | Diff. | Pts. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Racing de Córdoba | 28 | 18 | 8 | 2 | 49:14 | 35 | 62 |
| 2 |
|
Sarmiento de Resistencia | 28 | 17 | 8 | 3 | 40:15 | 25 | 59 |
| 3 |
|
San Martín de Formosa | 28 | 16 | 6 | 6 | 53:27 | 26 | 54 |
| 4 |
|
Central Norte | 28 | 15 | 8 | 5 | 41:22 | 19 | 53 |
| 5 |
|
Gimnasia y Tiro de Salta | 28 | 13 | 7 | 8 | 27:27 | 0 | 46 |
| 6 |
|
Douglas Haig | 29 | 12 | 7 | 10 | 39:30 | 9 | 43 |
| 7 |
|
Sportivo Las Parejas | 28 | 10 | 9 | 9 | 30:28 | 2 | 39 |
| 8 |
|
Belgrano de San Francisco | 28 | 11 | 5 | 12 | 35:32 | 3 | 38 |
| 9 |
|
Gimnasia y Esgrima (CdU) | 28 | 11 | 5 | 12 | 28:32 | -4 | 38 |
| 10 |
|
Crucero del Norte | 29 | 10 | 7 | 12 | 24:38 | -14 | 37 |
| 11 |
|
Juventud Antoniana | 29 | 9 | 7 | 13 | 26:38 | -12 | 34 |
| 12 |
|
Boca Unidos | 28 | 7 | 11 | 10 | 29:32 | -3 | 32 |
| 13 |
|
Defensores Belgrano (VR) | 29 | 8 | 5 | 16 | 24:35 | -11 | 29 |
| 14 |
|
Defensores de Pronunciamiento | 28 | 6 | 9 | 13 | 22:35 | -13 | 27 |
| 15 |
|
Unión de Sunchales | 28 | 7 | 5 | 16 | 27:44 | -17 | 26 |
| 16 |
|
Atlético Paraná | 28 | 5 | 7 | 16 | 21:41 | -20 | 22 |
| 17 |
|
Juventud Unida de Gualeguaychú | 28 | 6 | 4 | 18 | 24:49 | -25 | 22 |
| Play-off |
